Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Barium Binding to EF-Hand Proteins and Potassium Channels

  • Vladimir N. Uversky
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_168



Barium can effectively interact with several EF-hand calcium-binding proteins. This metal ion is also considered as a potent inhibitor of the regulated potassium channels. It also can inactivate some calcium channels.

Some Physicochemical Properties of Barium

The chemical element barium is the 56th element in the chemical periodic table with the symbol of Ba, atomic number of 56, and atomic mass of the 137.33. It belongs to the group 2 (of which it is a fifth element) in the periodic table. Therefore, barium, which is a soft, silvery-white metal, with a slight golden shade when ultrapure, and highly reactive metal, is the heaviest nonradioactive member of the alkaline-earth elements. Barium is a relatively common element in Earth (it has a concentration of 0.0425% in the Earth’s crust and 13 μg/L in sea water, being 14th in natural...

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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Molecular MedicineUniversity of South Florida, College of MedicineTampaUSA