Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Rubredoxin, Interaction with Germanium

  • Griselda Hernández
  • David M. LeMaster
  • Janet S. Anderson
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_124

Synonyms

Definition

The tetracysteine metal coordination site of the rubredoxins from the eubacterium Clostridium pasteurianum and the hyperthermophilic archaeon Pyrococcus furiosus forms kinetically stable coordination with the inorganic Ge(IV) ion.

Clinical Toxicity of Inorganic Germanium Complexes

Inorganic germanium(IV) forms coordination complexes with a wide range of O, N, and S-bearing ligands (Holloway and Melnik 2001). Elsewhere in this volume, the potential utility of a small molecule germanium complex as a radioprotectant for whole body γ-irradiation treatment is considered. Unfortunately, during the past several decades, the clinical relevance of germanium ion coordination has been dominated by the marketing of elixirs containing citrate and lactate coordination complexes of inorganic Ge(IV) that are proposed to treat numerous types of severe maladies (Tao and Bolger 1997). A number of fatalities have resulted, primarily due to...

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References

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Griselda Hernández
    • 1
  • David M. LeMaster
    • 1
  • Janet S. Anderson
    • 2
  1. 1.New York State Department of HealthWadsworth CenterAlbanyUSA
  2. 2.Department of ChemistryUnion CollegeSchenectadyUSA