Rubredoxin, Interaction with Germanium
The tetracysteine metal coordination site of the rubredoxins from the eubacterium Clostridium pasteurianum and the hyperthermophilic archaeon Pyrococcus furiosus forms kinetically stable coordination with the inorganic Ge(IV) ion.
Clinical Toxicity of Inorganic Germanium Complexes
Inorganic germanium(IV) forms coordination complexes with a wide range of O, N, and S-bearing ligands (Holloway and Melnik 2001). Elsewhere in this volume, the potential utility of a small molecule germanium complex as a radioprotectant for whole body γ-irradiation treatment is considered. Unfortunately, during the past several decades, the clinical relevance of germanium ion coordination has been dominated by the marketing of elixirs containing citrate and lactate coordination complexes of inorganic Ge(IV) that are proposed to treat numerous types of severe maladies (Tao and Bolger 1997). A number of fatalities have resulted, primarily due to...
- Holloway CE, Melnik M (2001) Germanium coordination compounds: classification and analysis of crystallographic and structural data. Main Group Met Chem 24:681–726Google Scholar