Bismuth in Brain, Distribution
Encephalopathy: This term involves a large group of transient or permanent brain disorders with very diverse etiologies. Among other causes it can be mentioned metabolic alterations, bacterial, food poisoning, trauma, hypoxia, pharmacological, etc. When unresolved, encephalopathies lead to neurodegeneration. The hallmark of encephalopathy is mental alteration, impairment of cognitive functions, lethargy, confusion, tremors, seizures, convulsions, and others.
Autometallography: This method is used for the imaging of metal-containing clusters in tissues sections. This methodology involves the reduction of silver ions from a silver donor e.g., silver lactate (Ag+) to metallic silver (Ag0) by metals such as bismuth in the presence of a developer. In consequence, Ag0 is deposited in the site where the metal of interest is located and those deposits can be photographed by both light and electron microscopies.
In contrast to many other heavy metals,...
- Bes A et al (1976) Toxic encephalopathy due to bismuth salts. Rev Med Touluse 12:801–813Google Scholar
- Martin-Bouyer B (1978) Poisoning by orally administred bismuth salts. Gastrointest Clin Biol 2(4):349–356Google Scholar
- Palmieri Y (2004) About bismuth. htpp://www.bismuth.be/bismuthpdf
- Ross JF et al (1988) Characterization of a murine model for human bismuth encephaloapathy. Neurotoxicoly 9:581–586Google Scholar
- Slikkerveer A, de Wolff FA (1989) Pharmacokinetices and toxicity of bismuth compounds. Toxicol Manag Rev 4:303–323Google Scholar
- Stoltenberg M (2004) Bismuth. Some aspects of localization, transport and pathological effects of metalic bismuth and bismuth salts with special emphasis o nits neurotoxicity to man and experimental animals. Thesis, University of Aarhus, DenmarkGoogle Scholar
- Stoltenberg M, Danscher G. Histochemical differentiation of autometallographically traceable metals (Au, Ag, Bi, Zn): Protocols for chemical removal of separate autometallographic metal clusters in Epon Sections. Histochem J 32:645–652Google Scholar
- The Lancet (1857). 2:185–187Google Scholar