Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Bismuth in Brain, Distribution

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_117

Synonyms

Definitions

Encephalopathy: This term involves a large group of transient or permanent brain disorders with very diverse etiologies. Among other causes it can be mentioned metabolic alterations, bacterial, food poisoning, trauma, hypoxia, pharmacological, etc. When unresolved, encephalopathies lead to neurodegeneration. The hallmark of encephalopathy is mental alteration, impairment of cognitive functions, lethargy, confusion, tremors, seizures, convulsions, and others.

Autometallography: This method is used for the imaging of metal-containing clusters in tissues sections. This methodology involves the reduction of silver ions from a silver donor e.g., silver lactate (Ag+) to metallic silver (Ag0) by metals such as bismuth in the presence of a developer. In consequence, Ag0 is deposited in the site where the metal of interest is located and those deposits can be photographed by both light and electron microscopies.

In contrast to many other heavy metals,...

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References

  1. Bes A et al (1976) Toxic encephalopathy due to bismuth salts. Rev Med Touluse 12:801–813Google Scholar
  2. Cassano GB et al (1969) The distribution of inhaled mercury (Hg203) vapors in the brain of rats and mice. J Neuropathol Exp Neurol 28:214–255CrossRefGoogle Scholar
  3. Larsen A et al (2005) In vivo distribution of bismuth in the mouse brain; influence of long-term survival and intracranial placement on the uptake and transport of bismuth in neuronal tissue. Basic Clin Pharmacol Toxicol 97(3):188–196PubMedCrossRefGoogle Scholar
  4. Martin-Bouyer B (1978) Poisoning by orally administred bismuth salts. Gastrointest Clin Biol 2(4):349–356Google Scholar
  5. Martin-bouyer G et al (1981) Epidemiological study of encephalopathies following bismuth administration per os. Characteristics of intoxicated subjects: comparison with control group. Clin Toxicol 11:1277–1283CrossRefGoogle Scholar
  6. Møller-Madsen B (1993) Localization of mercury in CNS of the ratII interperitoneal injection of methylmercuric chloride (CH3HgCl) and mercuric chloride (HgCl2). Toxicol Appl Pharmacol 103:303–323CrossRefGoogle Scholar
  7. Palmieri Y (2004) About bismuth. htpp://www.bismuth.be/bismuthpdf
  8. Pamphlett R et al (2000) Tissue Uptake of bismuth from shotgun pellets. Envion Res 82(3):258–262CrossRefGoogle Scholar
  9. Rokkas T, Sladen GE (1988) Bismuth: effects on gastritis and peptic ulcer. Scand J Gastroentral Suppl 142:82–86CrossRefGoogle Scholar
  10. Ross JF et al (1988) Characterization of a murine model for human bismuth encephaloapathy. Neurotoxicoly 9:581–586Google Scholar
  11. Ross JF et al (1994) Highest brain bismuth levels and neuropathology are adjeacent to fenestrated blood vessels in mouse brain after intraperitonal dosing of bismuth subnitrate. Toxicol Appl Pharmacol 124:191–200PubMedCrossRefGoogle Scholar
  12. Ross JF et al (1996) Distribution of bismuth in the brain: intraperitoneal dosing of bismuth subnitratein mice: implications for the route of entry of xenobiotic metals into the brain. Brain Res 725:137–154PubMedGoogle Scholar
  13. Rungby J, Danscher G (1983) Localization of exogenous silver in brain and spinal cord of silver exposed rats. Acta Neuropathol 60:92–98PubMedCrossRefGoogle Scholar
  14. Slikkerveer A, de Wolff FA (1989) Pharmacokinetices and toxicity of bismuth compounds. Toxicol Manag Rev 4:303–323Google Scholar
  15. Stoltenberg M (2004) Bismuth. Some aspects of localization, transport and pathological effects of metalic bismuth and bismuth salts with special emphasis o nits neurotoxicity to man and experimental animals. Thesis, University of Aarhus, DenmarkGoogle Scholar
  16. Stoltenberg M, Danscher G. Histochemical differentiation of autometallographically traceable metals (Au, Ag, Bi, Zn): Protocols for chemical removal of separate autometallographic metal clusters in Epon Sections. Histochem J 32:645–652Google Scholar
  17. Stoltenberg M et al Autometallographic tracing of bismuth in human brain autopsies. J Neuropathol Exp Neurol 60:705–710PubMedGoogle Scholar
  18. Stoltenberg M et al (2001) Histochemical tracing of bismuth in Heliocobacter pylori after in vitro exposure to bismuth citrate. Scand J Gastroenterol 36(2):144–148PubMedCrossRefGoogle Scholar
  19. Stoltenberg M et al (2001) Retrograde axonal transport of bismuth. An autometallograhic study. Acta Neuropathol 101:123–128PubMedGoogle Scholar
  20. Stoltenberg M et al (2003) In vivo cellular uptake of bismuth ions from shotgun pellets. Histol Histopathol 18(3):781–785PubMedGoogle Scholar
  21. Stoltenberg M, Juhl S, Danscher G (2007) Bismuth ions are metabolized into autometallographic traceable bismuth-sulphur quantum dots. Eur J Histochem 51(1):53–57PubMedGoogle Scholar
  22. The Lancet (1857). 2:185–187Google Scholar
  23. Tiekink ER (2002) Antimony and bismuth compounds in oncology. Crti Rev Oncol 42(3):217–224CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Biomedicine/Pharmacology HealthAarhus UniversityAarhusDenmark