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Synopsis
The structure of a protein is critical to its proper function. The proper function of proteins is critical to life itself. What kinds of structures can a polymer made of amino acids adopt? The possibilities are constrained, both by the identity of the amino acid side chains and also by the nature of the amide bond that connects them. Conventionally, the medium-scale structural unit of a polypeptide chain is referred to as its secondary structure. The three secondary structure elements are the alpha helix, the beta-sheet, and the turn. This review examines each type of secondary structure and touches on contemporary research questions regarding secondary structure.
Introduction
The three-dimensional structure of proteins is a subject of truly fundamental importance to biochemistry (Petsko and Ringe 2004). Of the matter of which living things are made, the polymers known...
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References
Anslyn EV, Dougherty DA (2006) Modern physical organic chemistry. University Science Books, Sausalito
Dill KA, MacCallum JL (2012) The protein-folding problem, 50 years on. Science 338(6110):1042–1046
Knowles TPJ, Vendruscolo M, Dobson CM (2014) The amyloid state and its association with protein misfolding diseases. Nat Rev Mol Cell Biol 15(6):384–396
Kuriyan J, Konforti B, and Wemmer D (2012) The molecules of life: physical and chemical principles. Garland Science
Neira J (ed) (2013) Archives of biochemistry and biophysics. Special issue. Protein Folding and Stability 531(1–2):1–135
Petsko GA, Ringe D (2004) Protein Structure and Function. New Science Press, London
Tomasini C, Huc I, Aitken DJ, Fülöp F (2013) Foldamers. Eur J Org Chem 2013(17):3408–3409
Valastyan JS, Lindquist S (2014) Mechanisms of protein-folding diseases at a glance. Dis Model Mech 7(1):9–14
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Brandt, G.S. (2018). Secondary Structure. In: Wells, R.D., Bond, J.S., Klinman, J., Masters, B.S.S. (eds) Molecular Life Sciences. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1531-2_8
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DOI: https://doi.org/10.1007/978-1-4614-1531-2_8
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Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-1529-9
Online ISBN: 978-1-4614-1531-2
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