Molecular Life Sciences

2018 Edition
| Editors: Robert D. Wells, Judith S. Bond, Judith Klinman, Bettie Sue Siler Masters

Repeating Sequences in Proteins: Their Identification and Structural/Functional Implications

  • David A. D. Parry
Reference work entry



Sequence repeats, whether they occur within a single protein or, alternatively, as a feature observed in a diverse range of proteins, are widespread in nature. However, a particular repeat can vary both in length and in the degree of inter-repeat identity. Where the repeat length is short and multiple copies of it are found contiguously, the protein is likely to form a long structural element. This aids assembly into the filamentous structures that are the characteristic of fibrous proteins. Alternatively, in those cases where the repeats are well separated from one another within the sequence, the repeats are more likely to have functional rather than structural importance. This is also true for those sequence motifs that occur but once in a single protein but which are nonetheless found in a diverse range of other proteins. The repeats observed to date can, for convenience, be...

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Copyright information

© Springer Science+Business Media, LLC 2018

Authors and Affiliations

  1. 1.Institute of Fundamental Sciences and Riddet InstituteMassey UniversityPalmerston NorthNew Zealand