Recombination: Mechanisms, Pathways, and Applications
Recombination is a process that brings about reassortment of genetic information in and among chromosomes. Recombination serves several functions in organisms, including DNA repair in bacteria and eukaryotes, and ensures the correct alignment and segregation of chromosomes during meiosis in eukaryotes. Recombination is thought to be important for evolution since it provides new combinations of genes that may give rise to beneficial traits in an organism. Recombination enzymes and pathways are also used in some specialized cellular functions such as the diversification of genes that encode antibody proteins in vertebrates (V(D)J recombination) and telomere maintenance in tumor cells. Homologous recombination relies on complementary DNA sequences to transfer genetic information between identical and nearly identical (homologous) chromosomes. Genetic rearrangements can also occur through site-specific recombination and transposition reactions that are directed by protein-DNA...
- Batey MA, Zhao Y, Kyle S, Richardson C, Slade A, Martin NM, Lau A, Newell DR, Curtin NJ (2013) Preclinical evaluation of a novel ATM inhibitor, KU59403, in vitro and in vivo in p53 functional and dysfunctional models of human cancer. Mol Cancer Ther 12:959–967PubMedPubMedCentralCrossRefGoogle Scholar
- Campbell A (1961) Episomes. Adv Genet 11:101–145Google Scholar
- https://www.sheffield.ac.uk/mbb/ruva. Accessed 24 May 2017
- Jackson DA, Symons RH, Berg P (1972) Biochemical method for inserting new genetic information into DNA of Simian Virus 40: circular SV40 DNA molecules containing lambda phage genes and the galactose operon of Escherichia coli. Proc Natl Acad Sci U S A 69:2904–2909PubMedPubMedCentralCrossRefGoogle Scholar
- Keller EF (1983) A feeling for the organism. W. H. Freeman and Co., New YorkGoogle Scholar
- Stahl FW (1979) Genetic recombination. Thinking about it in phage and fungi. W. H. Freeman and Co., San FranciscoGoogle Scholar