Celiac Disease

Reference work entry

Celiac disease is a gastrointestinal disorder characterized by chronic inflammation of the small intestine that can develop in genetically susceptible individuals ingesting proteins in wheat (gliadin), rye (secalin), and barley (hordein), collectively called gluten. The prevalence of celiac disease in the United States and Canada is as high as 0.5–1%, similar to earlier estimates outside North America.

Synonyms and Related Disorders

Celiac sprue; Gluten sensitive enteropathy

Genetics/Basic Defects

  1. 1.
    1. a.

      Celiac disease occurs in genetically susceptible individuals who ingest gluten, a protein found in certain grains

    2. b.

      Gluten causes an abnormal T cell–mediated immune response and inflammatory injury to the mucosa of the small intestine, resulting in malabsorption of nutrients in these individuals

    3. c.

      Gliadin fraction of gluten is mainly responsible for this intestinal damage

    4. d.

      Approximately 97% of individuals with celiac disease have genetic markers on chromosome 6...


Irritable Bowel Syndrome Celiac Disease Human Leukocyte Antigen Down Syndrome Turner Syndrome 
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