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Triacanthine

Reference work entry

CAS Registry Number: 10091-84-6 Open image in new window

Taxonomy: Physicochemical and Pharmacological Properties of Alkaloids – Miscellaneous Alkaloids

Biological sources: Gleditschia triacanthos

C10H13N5: 203.1171

Mp: 227–228°C, 241°C (picrate), 219°C (hydrochloride), 216°C (hydrobromide), 203°C (methiodide) [1]; 228–229°C [2]

UV: 272(4.10) [1], 273 [2]

IR: 3370, 3250, 1684, 1630, 1556, 1517, 1341, 1289, 1279, 1235, 1225, 1210, 1176, 1118, 1087, 1058, 1041, 1018, 957, 943, 922, 873, 847, 806, 779 [3]

Pharm./Biol.: LD50 259, 147, 500 mg/kg (i/p, i/v, per os, mice). Papaverin-like adrenolytic action. It dilates vessels, decreases tonus and contractile activity of uterus, and exerts the favorable effect in ulcerous disease, spastic colitis, bronchial asthma, hypertension [4]

References

  1. 1.
    A.S. Belikov, E.S. Zheleznova, Trudy VILAR 11, 22 (1959)Google Scholar
  2. 2.
    N.J. Leonard, J.A. Deyrup, J. Am. Chem. Soc. 84(11), 2148 (1962)CrossRefGoogle Scholar
  3. 3.
    J. Holubek, O. Strouf, Spectral Data and Physical Constants of Alkaloids (Prague Publishing House, Czechoslovak Academy of Sciences/Heyden & Son, London, 1966), 2, No. 273Google Scholar
  4. 4.
    F.S. Sadritdinov, A.G. Kurmukov, The Pharmacology of the Plant Alkaloids and Their Use in Medicine [in Russian] (UzSSR, Tashkent, 1980), p. 149Google Scholar

Copyright information

© Springer Science+Business Media New York 2013

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