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Ergometrine

Reference work entry

CAS Registry Number: 60-79-7 Open image in new window

Taxonomy: Physicochemical and Pharmacological Properties of Alkaloids – Miscellaneous Alkaloids

Biological sources: Claviceps purpurea

C19H23N3O2: 325.1790

Mp: 157–158°C (dec., C6H6) [1], 246°C (hydrochloride), 239°C (dec., hydrobromide), 190°C (dec., oxalate) [1]

[α]D +40° (EtOH) [1]

Solubility: very sol. MeOH, EtOH, Me2CO; insol. H2O, C6H6, CHCl3 [1]

IR: [1]

MSm/z: 325(M+), 223, 221, 207, 196, 192, 167, 154, 111 [2]

HPLC: [3]

Pharm./Biol.: LD50 0.15 mg/kg (i/v, mice), 6 mg/kg (i/v, rabbits). Uterine action. It is used with the aim of reduction of the duration of the third period of labor [4]

References

  1. 1.
    A.N. Ban’kovskaya, A.I. Ban’kovskii, Trudy VILAR, Lekarstvennye rasteniya 15, 368 (1969)Google Scholar
  2. 2.
    A.N. Ban’kovskaya, V.I. Sheichenko, A.I. Ban’kovskii, L.D. Vechkanova, V.S. Kabanov, Chem. Nat. Comp. 9, 139 (1973)CrossRefGoogle Scholar
  3. 3.
    H. Potter, M. Hulm, S. Schumann, J. Chromatogr. 319, 440 (1985)CrossRefGoogle Scholar
  4. 4.
    F.S. Sadritdinov, A.G. Kurmukov, The Pharmacology of the Plant Alkaloids and Their Use in Medicine [in Russian] (UzSSR, Tashkent, 1980), p. 109Google Scholar

Copyright information

© Springer Science+Business Media New York 2013

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