Coffeine (Caffeine)

Reference work entry

CAS Registry Number: 58-08-2 Open image in new window

Taxonomy: Physicochemical and Pharmacological Properties of Alkaloids – Miscellaneous Alkaloids

Biological sources: Thea sinensis

C8H10N4O2: 194.0804

Mp: 232–235°C (Me2CO) [1]

UV: 273(3.99) [1]

IR: 3130–3120, 1715, 1700, 1668, 1560, 1487, 980, 761, 750 [1, 2, 3]

MSm/z: 194, 165, 137, 109, 82, 67, 55 [4, 5]

1H NMR: 3.44, 3.50, 3.92(each 3H, s, 3 × NCH3), 7.44(1H, s) [1]

GLC: [2]

HPLC: [6]

Pharm./Biol.: Causes a permanent increase in mental activity and total working capacity [7]. Weakens the action of hypnotics and narcotics, stimulates respiration, and lowers thrombocyte aggregation. Used in infectious and other diseases accompanied by depression of the CNS and the cardiovascular system, spasms of the vessels of the brain, etc. Supplied in the form of a powder. In combination with analgesics, it is a component of the tablets Askofen, Tsitramone, Coffetamine, etc. [8]

References

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    P. Mazzafera, A. Crozier, A.C. Magalhaes, Phytochemistry 30, 3913 (1991)CrossRefGoogle Scholar
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    M.A. Bokuchava, The Biochemistry of Tea Production [in Russian] (Akad. Nauk SSSR, Moscow, 1958), p. 52Google Scholar
  8. 8.
    M.D. Mashkovskii, Drugs [in Russian], vol. 1 (Meditsina, Moscow, 1998), p. 118Google Scholar

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