Taxonomy: Physicochemical and Pharmacological Properties of Alkaloids – Quinolizidine Alkaloids
Biological sources: Anabasis aphylla
C16H28N2O2: 280.2151
Mp: 80–81°C (Me2CO), 250°C (MeOH, hydrochloride), 258°C (EtOH, hydrobromide), 241°C (EtOH, hydroiodide), 220°C (EtOH, picrate) [1]
[α]D +20° (EtOH)
IR: 1740 [1]
MS m/z: 280(M+), 208, 149, 136, 124, 123, 122, 110, 98, 97, 84, 83, 69, 68 [2]
Pharm./Biol.: LD50 410 mg/kg (i/p, mice). Depresses the orientation reactions of white mice, prolongs the action of hypnotics, and exhibits a weak analgesic action [3]. Tranquilizing, weak hypotensive, and broncholytic effect [4]
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References
Kh.A. Aslanov, S.Z. Mukhamedzhanov, A.S. Sadykov, Nauch. Tr. TashGu. (286), 71 (1966)
E.Kh. Timbekov, F.Sh. Eshbaev, Kh.A. Aslanov, A.S. Sadykov, A.I. Ishbaev, T.K. Kasymov, Chem. Nat. Comp. 8, 196 (1972)
F.S. Sadritdinov, A.G. Kurmukov, The Pharmacology of the Plant Alkaloids and Their Use in Medicine [in Russian] (UzSSR, Tashkent, 1980), p. 105
S.Kh. Nasirov, The Pharmacology of Plant Substances [in Russian] (Fan, Tashkent, 1973), p. 60
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(2013). Methyl Ester of Aphyllinic Acid. In: Azimova, S.S., Yunusov, M.S. (eds) Natural Compounds. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0560-3_1246
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DOI: https://doi.org/10.1007/978-1-4614-0560-3_1246
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