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Methyl Ester of Aphyllinic Acid

Reference work entry

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Taxonomy: Physicochemical and Pharmacological Properties of Alkaloids – Quinolizidine Alkaloids

Biological sources: Anabasis aphylla

C16H28N2O2: 280.2151

Mp: 80–81°C (Me2CO), 250°C (MeOH, hydrochloride), 258°C (EtOH, hydrobromide), 241°C (EtOH, hydroiodide), 220°C (EtOH, picrate) [1]

[α]D +20° (EtOH)

IR: 1740 [1]

MSm/z: 280(M+), 208, 149, 136, 124, 123, 122, 110, 98, 97, 84, 83, 69, 68 [2]

Pharm./Biol.: LD50 410 mg/kg (i/p, mice). Depresses the orientation reactions of white mice, prolongs the action of hypnotics, and exhibits a weak analgesic action [3]. Tranquilizing, weak hypotensive, and broncholytic effect [4]

References

  1. 1.
    Kh.A. Aslanov, S.Z. Mukhamedzhanov, A.S. Sadykov, Nauch. Tr. TashGu. (286), 71 (1966)Google Scholar
  2. 2.
    E.Kh. Timbekov, F.Sh. Eshbaev, Kh.A. Aslanov, A.S. Sadykov, A.I. Ishbaev, T.K. Kasymov, Chem. Nat. Comp. 8, 196 (1972)CrossRefGoogle Scholar
  3. 3.
    F.S. Sadritdinov, A.G. Kurmukov, The Pharmacology of the Plant Alkaloids and Their Use in Medicine [in Russian] (UzSSR, Tashkent, 1980), p. 105Google Scholar
  4. 4.
    S.Kh. Nasirov, The Pharmacology of Plant Substances [in Russian] (Fan, Tashkent, 1973), p. 60Google Scholar

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© Springer Science+Business Media New York 2013

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