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Matrine

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CAS Registry Number: 519-02-8

Taxonomy: Physicochemical and Pharmacological Properties of Alkaloids – Quinolizidine Alkaloids

Biological sources: Ammothamnus lehmannii, Leontice alberti, Sophora alopecuroides, S. flavescens, S. griffithii, S. japonica, S. pachycarpa, Vexibia pachycarpa

C15H24N2O: 248.1889

Mp: 77°C (α-form), 87°C (β-form), oil (γ-form), 84°C (δ-form) [1]; 214°C (perchlorate), 275°C (hydrobromide), 211°C (methiodide) [1, 2]

[α]D +38° (EtOH) [1]

IR: 2795, 2750, 2700, 2690 [3]

MS m/z: 248(M+, 73), 247(100), 219(8), 205(29), 177(23), 150(63), 136(26), 98(26), 96(67), 41(54) [4]; 248(M+, 100), 247(98.7), 233(2.6), 219(19), 205(78), 192(20), 177(24), 162(28), 150(61), 137(36), 130(8), 122(22), 110(13), 98(45), 97(11), 96(49), 83(34), 55(34) [5]

1 H NMR: 3.00(1H, dd, J = 12.5, 12.5, 4, Ha-17), 3.81(1H, m, H-11), 4.42(1H, dd, J = 12.5, 4, He-17) [6]

13 C NMR: [7]

Table 1

C-2

57.2

C-6

63.7

C-11

53.1

 3

20.7

 7

41.3

 12

27.8

 4

27.1

 8

26.4

 13

18.9

 5

35.3

 9

21.2

 14

32.8

   

 10

57.2...

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References

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(2013). Matrine. In: Azimova, S.S., Yunusov, M.S. (eds) Natural Compounds. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0560-3_1242

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