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Control of Left Ventricular Assist Devices

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Encyclopedia of Systems and Control
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Abstract

Heart failure is a disease that happens when the heart cannot pump enough oxygenated blood into the circulatory system to support other organs in the body. A left ventricular assist device (or LVAD) is a mechanical pump that may be implanted in patients who suffer from advanced heart failure to assist their heart in its pumping function. The pump is connected from the left ventricle to the aorta and forms a parallel path of blood flow into the circulatory system. The latest generation of these devices consists of rotary pumps, which are generally much smaller, lighter, and quieter than the first-generation pulsatile-type pumps. The LVAD is controlled by varying the pump rotor speed to adjust the amount of blood flow contributed by the device. If the patient is in a healthcare facility, the rotor speed can be adjusted manually by a trained clinician. An important limitation facing the increased use of these devices is the desire to allow the patient to return home and resume a normal lifestyle. This limitation may be overcome if a physiological controller can be developed to automatically adjust the pump speed based on the patient’s need for blood flow. Although several possible experimental controllers have recently been developed and tested in laboratory settings, the current practice remains limited to the pump speed being adjusted by the physician and fixed at a constant setting before allowing the patient to leave the healthcare facility. The development of a physiological controller for the continuous flow rotary LVAD remains an important challenge that has occupied LVAD researchers and engineers for the past several decades.

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Bibliography

  • Alomari AHH, Savkin AV, Stevens M, et al (2013) Developments in control systems for rotary left ventricular assist devices for heart failure patients: a review. Physiol Meas 34:R1–R27

    Article  Google Scholar 

  • Antaki JF, Boston JR, Simaan MA (2003) Control of heart assist devices. In: Proceedings of IEEE conference on decision and control, Maui, 9–12 Dec, pp 4084–4089

    Google Scholar 

  • Baloa LA, Liu D, Boston JR, Simaan MA, Antaki JF (2000) Control of rotary heart assist devices. In: Proceedings of American control conference, Chicago, 28–30 June, pp 2982–2986

    Google Scholar 

  • Boston JR, Simaan MA, Antaki JF, Yu Y-C, Choi S (1998) Intelligent control design of heart assist devices. In: Proceedings of the IEEE 1998 international symposium on intelligent control, computational intelligence in robotics and automation, and intelligent systems and semiotics: a joint conference on the science and technology of intelligent systems. National Institute of Standards and Technology, Gaithersburg, 14–17 Sept, pp 497–502

    Google Scholar 

  • Boston JR, Baloa LA, Liu D, Simaan MA, Choi S, Antaki JF (2000a) Combination of data approaches to heuristic control and fault detection. In: Proceedings of the IEEE conference on control applications and international symposium on computer-aided control systems design, Anchorage, 25–27 Sept, pp 98–103

    Google Scholar 

  • Boston JR, Simaan MA, Antaki JF, Yu Y-C (2000b) Control issues in rotary heart assist devices. In: Proceedings of the American control conference, Chicago, 28–30 June, pp 3473–3477

    Google Scholar 

  • Boston JR, Antaki JF, Simaan MA (2003) Hierarchical control for hearts assist devices. IEEE Robot Autom Mag 10(1):54–64

    Article  Google Scholar 

  • Bullister E, Reich S, Sluetz J (2002) Physiologic control algorithms for rotary blood pumps using pressure sensor input. Artif Organs 26:931–938

    Article  Google Scholar 

  • Faragallah G, Simaan MA (2013) An engineering analysis of the aortic valve dynamics in patients with left ventricular assist devices. J Healthcare Eng 4(3):307–327

    Article  Google Scholar 

  • Faragallah G, Wang Y, Divo E, Simaan MA (2011) A new current-based control model of the combined cardiovascular and rotary left ventricular assist device. In: Proceedings of the 2011 American control conference, San Francisco, 29 June – 1 July, pp 4776–4780

    Google Scholar 

  • Faragallah G, Wang Y, Divo E, Simaan MA (2012) A new control system for left ventricular assist devices based on patient-specific physiological demand. Inverse Prob Sci Eng 20(5):721–34

    Article  Google Scholar 

  • Frazier H, Myers TJ (1999) Left ventricular assist systems as a bridge to myocardial recovery. Ann Thoracic Surg 68:734–741

    Article  Google Scholar 

  • Giridharan GA, Skliar M, Olsen DB, Pantalos GM (2002) Modeling and control of a brushless DC axialf low ventricular assist device. Am Soc Artif Int Organ (ASAIO) J 48:272–289

    Article  Google Scholar 

  • Jakovljevic DG, Yacoub MH, Schueler S et al (2017) Left ventricular assist device as a bridge to recovery for patients with advanced heart failure. J Am Coll Cardiol 69(15):1924–1933

    Article  Google Scholar 

  • Kirklin JK, Pagani FD, Kormos RL, Stevenson LW, Blume ED, Myers SL, Miller MA, Baldwin JT, Young JB, Naftel DC (2017) Eighth annual intermacs report: special focus on framing the impact of adverse events. J Heart Lung Transplant 36:1080–1086

    Article  Google Scholar 

  • Levin R, Dolgin M, Fox C, Gorlin R (1994) The criteria committee of the New York heart association. In: Nomenclature and criteria for diagnosis of diseases of the heart and great vessels, LWW handbooks 9:253–256

    Google Scholar 

  • Mansouri M, Salamonsen RF, Lim E, Akmeliawati R, Lovell NH (2015) Preload-based starling-like control for rotary blood pumps: numerical comparison with pulsatility control and constant speed operation. PLoS One 10:e0121413

    Article  Google Scholar 

  • Marieb E (1994) Human anatomy and physiology. Pearson Education, San Francisco

    Google Scholar 

  • Mason D, Hilton A, Salamonsen R (2008) Reliable suction detection for patients with rotary blood pumps. Am Soc Artif Int Organ (ASAIO) J 54:359–366

    Article  Google Scholar 

  • Moscato F, Arabia M, Colacino FM, Naiyanetr P, Danieli GA, Schima H (2010) Left ventricle afterload impedance control by an axial flow ventricular assist device: a potential tool for ventricular recovery. Artif Organ 34:736–744

    Article  Google Scholar 

  • Mozzafarian D, Benjamin EJ, Go AS et al (2016) On behalf of the American heart association statistics committee and stroke statistics subcommittee. Heart disease and stroke statistics—2016 update: a report from the American Heart Association. Circulation 133:e38–e360

    Google Scholar 

  • Ochsner G, Amacher R, Wilhelm MJ et al (2013) A physiological controller for turbodynamic ventricular assist devices based on a measurement of the left ventricular volume. Artif Organ 38:527–538

    Article  Google Scholar 

  • Olsen D (2000) The history of continuous-flow blood pumps. Artif Organ 24(6):401–404

    Article  Google Scholar 

  • Petrou A, Lee J, Dual S, Ochsner G, Meboldt M, Daners MS (2018) Standardized comparison of selected physiological controllers for rotary blood pumps: in vitro study. Artif Organ 42(3):E29–E42

    Article  Google Scholar 

  • Poirier VL (1997) The LVAD: a case study. The Bridge 27:14–20

    Google Scholar 

  • Prinzing P, Herold ULF, Berkefeld A, Krane M, Lange R, Voss B (2016) Left ventricular assist devices—current state and perspectives. J Thorac Dis 8(8):E660–E666

    Article  Google Scholar 

  • Shima H, Trubel W, Moritz A, Wieselthaler G, Stohr H, Thomas H, Losert U, Wolner E (1992) Noninvasive monitoring of rotary blood pumps: necessity, possibilities, and limitations. Artif Organ 14(2):195–202

    Google Scholar 

  • Silverthorn DU (2000) Human physiology: an integrated approach, 2nd edn. Benjamin/Cummings Publishing, New York

    Google Scholar 

  • Simaan MA, Ferreira A, Chen S, Antaki JF, Galati D (2009) A dynamical state-space representation and performance analysis of a feedback-controlled rotary left ventricular assist device. IEEE Trans Control Syst Technol 1(17):15–28

    Article  Google Scholar 

  • Simaan MA, Faragallah G, Wang Y, Divo E (2011) Left ventricular assist devices: engineering design considerations, chap. 2. In: Reyes G (ed) New aspects of ventricular assist devices. Intech Publishers, pp 21–42

    Google Scholar 

  • Simon MA, Kormos RL, Murali S et al (2005) Myocardial recovery using ventricular assist devices: prevalence, clinical characteristics, and outcomes. Circulation 112(9 suppl):I-32-I-36

    Google Scholar 

  • Stergiopulos N, Meister J, Westerhof N (1996) Determinants of stroke volume and systolic and diastolic aortic pressure. Am J Physiol 270(6):H2050–59

    Google Scholar 

  • Suga H, Sagawa K (1974) Instantaneous pressure volume relationships and their ratio in the excised, supported canine left ventricle. Circ Res 35(1):117–126

    Article  Google Scholar 

  • Vollkron M, Chima H, Huber L, Benkowski R, Morello G, Wieselthaler G (2006) Advanced suction detection for an axial flow pump. Artif Organ 30(9):665–670

    Article  Google Scholar 

  • Wang Y, Simaan MA (2013) A suction detection system for rotary blood pumps based on Lagrangian support vector machine algorithm. IEEE J Biomed Health Inform 17(3):654–663

    Article  Google Scholar 

  • Wang Y, Koenig SC, Slaughter MS, Giridharan GA (2015) Rotary blood pump control strategy for preventing left ventricular suction. Am Soc Artif Int Organ ASAIO J 61:21–30

    Article  Google Scholar 

  • Wu Y, Allaire PE, Tao G, Olsen DB (2007) Modeling, estimation, and control of human circulatory system with a left ventricular assist device. IEEE Trans Control Syst Technol 15(17):754–767

    Article  Google Scholar 

  • Yancy CW, Jessup M, Bozkurt B et al (2013) ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association task force on practice guidelines. J Am Coll Cardiol 62(16):e147–e239

    Article  Google Scholar 

  • Yuhki Y, Hatoh E, Nogawa M, Miura M, Shimazaki Y, Takatani S (1999) Detection of suction and regurgitation of the implantable centrifugal pump based on the motor current waveform analysis and its application to optimization of the pump flow. Artif Organ 23:532–537

    Article  Google Scholar 

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Correspondence to Marwan A. Simaan .

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Simaan, M.A. (2020). Control of Left Ventricular Assist Devices. In: Baillieul, J., Samad, T. (eds) Encyclopedia of Systems and Control. Springer, London. https://doi.org/10.1007/978-1-4471-5102-9_100135-1

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  • DOI: https://doi.org/10.1007/978-1-4471-5102-9_100135-1

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