Encyclopedia of Systems and Control

2015 Edition
| Editors: John Baillieul, Tariq Samad

Monotone Systems in Biology

  • David Angeli
Reference work entry
DOI: https://doi.org/10.1007/978-1-4471-5058-9_90


Mathematical models arising in biology might sometime exhibit the remarkable feature of preserving ordering of their solutions with respect to initial data: in words, the “more” of x (the state variable) at time 0, the more of it at all subsequent times. Similar monotonicity properties are possibly exhibited also with respect to input levels. When this is the case, important features of the system’s dynamics can be inferred on the basis of purely qualitative or relatively basic quantitative knowledge of the system’s characteristics. We will discuss how monotonicity-related tools can be used to analyze and design biological systems with prescribed dynamical behaviors such as global stability, multistability, or periodic oscillations.


Feedback interconnections Monotone dynamics Monotonicity checks 
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Copyright information

© Springer-Verlag London 2015

Authors and Affiliations

  1. 1.Department of Electrical and Electronic EngineeringImperial College LondonLondonUK
  2. 2.Dipartimento di Ingegneria dell’InformazioneUniversity of FlorenceFlorenceItaly