Definition
“ORF” (open reading frame) is a leafconcept of the “ FunctionalityType ” concept of identification (generated from the IDENTIFICATION Axiom) of IMGT-ONTOLOGY, the global reference in immunogenetics and immunoinformatics (Giudicelli and Lefranc 1999; Lefranc et al. 2004, 2005, 2008; Duroux et al. 2008), built by IMGT®, the international ImMunoGeneTics information system® (http://www.imgt.org) (IMGT® Information System).
“ORF” identifies, whatever the molecule type (MoleculeType), the functionality of Molecule_EntityType leafconcepts in undefined or germline configuration (Configuration Type), whose coding region has an open reading frame (ORF), but:
Alterations have been described in the splicing sites, recombination signals (Recombination Signal (RS)) and/or regulatory elements
And/or changes of conserved amino acids have been suggested by the authors to lead to uncorrect folding
And/or the entity is an orphon (Location Type)
“ORF” is one of the three leafconcepts (the other...
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References
Duroux P, Kaas Q, Brochet X, Lane J, Ginestoux C, Lefranc M-P, Giudicelli V (2008) IMGT-Kaleidoscope, the Formal IMGT-ONTOLOGY paradigm. Biochimie 90:570–583
Giudicelli V, Lefranc M-P (1999) Ontology for immunogenetics: the IMGT-ONTOLOGY. Bioinformatics 12:1047–1054
Lefranc M-P, Giudicelli V, Ginestoux C, Bosc N, Folch G, Guiraudou D, Jabado-Michaloud J, Magris S, Scaviner D, Thouvenin V, Combres K, Girod D, Jeanjean S, Protat C, Yousfi Monod M, Duprat E, Kaas Q, Pommié C, Chaume D, Lefranc G (2004) IMGT-ONTOLOGY for immunogenetics and immunoinformatics. In Silico Biol 4:17–29
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Lefranc M-P, Giudicelli V, Regnier L, Duroux P (2008) IMGT, a system and an ontology that bridge biological and computational spheres in bioinformatics. Brief Bioinform 9:263–275
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Lefranc, MP. (2013). Open Reading Frame (ORF). In: Dubitzky, W., Wolkenhauer, O., Cho, KH., Yokota, H. (eds) Encyclopedia of Systems Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9863-7_672
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DOI: https://doi.org/10.1007/978-1-4419-9863-7_672
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