Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Ontology Analysis of Biological Networks

  • Jiguang Wang
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_487


Ontology analysis of biological networks is the strategy to discover the biological implications via identifying significantly enriched annotated ontology terms in networks or subnetworks.


According to the accumulation of different types of experimental data and prior knowledge, more and more biological networks are constructed to discover the underlying mechanisms of cell in a system level. At the same time, the demand for strategies to analyze and mine biological meanings from these resulting networks increases quickly.  Function enrichment analysis is an important way to fill the requirement. An efficient way to accurately describe function of gene is to use the  ontology structure ( ontology) of GO ( Gene Ontology) terms.

The Importance of Ontology Analysis

 Ontologywhich is a formal representation of knowledge is one of the most popular words in information science recently. To uniformly represent gene and gene product across databases and species,...

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Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.Beijing Institute of GenomicsChinese Academy of ScienceBeijingChina