One-Dimensional Diffusion is a class of the thermal motions of a protein molecule within long biopolymers such as DNA and RNA. The diffusion on DNA is divided into several modes. In sliding, a protein molecule tracks a DNA groove, while hopping, the molecule keeps contact with one side of a cylinder of ds DNA without tracking a groove. In intersegment transfer within the same DNA molecule, the molecule directly jumps from one segment to another without diffusing in the bulk solution when the two segments approach each other.
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