Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Optimal Experiment Design, Bayesian

  • Malcolm FarrowEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_1234


In the design of experiments, we choose what observations we will make and under what conditions. In Bayesian experimental design, we regard this choice as a decision and apply the ideas of Bayesian decision analysis ( Bayesian Decision Analysis). We take into account prior beliefs ( Bayesian Inference) about relevant unknown quantities and also the various costs and benefits associated with the experiment, where the benefits are typically a result of a gain in knowledge or reduction in uncertainty. The values that we place on these costs and benefits are expressed through a  utility function. We choose the design which maximizes our expectation, before the experiment, of the value of the utility function after the experiment. This does not necessarily mean that we use  Bayesian inference to analyze the results of the experiment.



The design of an experiment is a choice of what observations we are going to make or, in some cases, a rule for making...

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Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.School of Mathematics & StatisticsNewcastle UniversityNewcastle upon TyneUK