Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Optimal Experiment Design, Signal Transduction Pathways

  • Yunfei Chu
  • Juergen HahnEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_1226


 Optimal experiment design is a key component for building accurate models of  signal transduction pathways (Kreutz and Timmer 2009). Since experiment design is conducted prior to  parameter estimation, any experiment design procedure needs to explicitly be able to deal with parameter uncertainty.

For a mathematical definition of optimal experiment design, assume that a regression model is given by
$$ {\mathbf{y}} = {\mathbf{g}}\left( {{\mathbf{\theta }};{\mathbf{\xi }}} \right) $$
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Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.Artie McFerrin Department of Chemical EngineeringTexas A&M UniversityCollege StationUSA