Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Optimization Algorithms for Metabolites Production

  • Andrés Fernando González Barrios
  • Silvia Restrepo
  • Andrés Mauricio Pinzón Velasco
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_1172



Optimization algorithms for metabolite production are referred to in silico approaches intended to increase or optimize the synthesis of valuable products from the industrial perspective through using microorganisms. It generally departs from the metabolic reconstruction of the microorganism responsible for synthesizing such products. Due to the fact that the organisms display a dissimilar objective function compared to the industrial interest, optimization platforms are usually implemented based on bi-level programming frameworks where two objective functions are satisfied: ours and the organism.


Biotechnology research is partly aimed to decrease costs when designing bioprocess for producing high valuable products. This is reached through elaborating a parallel analysis of all factors influencing the process economics. Generally, biotransformation constitutes one...

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Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  • Andrés Fernando González Barrios
    • 1
  • Silvia Restrepo
    • 2
  • Andrés Mauricio Pinzón Velasco
    • 3
  1. 1.Department of Chemical EngineeringUniversidad de los AndesBogotáColombia
  2. 2.Department of Biological SciencesUniversidad de los AndesBogotáColombia
  3. 3.Department of Systems EngineeringUniversidad Jorge Tadeo LozanoBogotáColombia