Encyclopedia of Behavioral Medicine

2013 Edition
| Editors: Marc D. Gellman, J. Rick Turner

Pathophysiology

  • Michael Witthöft
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-1005-9_43

Definition

Pathophysiology (consisting of the Greek origin words “pathos” = suffering; “physis” = nature, origin; and “logos” = “the study of”) refers to the study of abnormal changes in body functions that are the causes, consequences, or concomitants of disease processes. Studies of pathophysiology are concerned with the investigation of biological processes that are directly related to disease processes of physical, mental, or psychophysiological conditions and disorders (e.g., alterations in the endocrine system, in certain neurotransmitters, or inflammatory parameters related to the activity of the immune system). Thus, pathophysiological research aims at identifying biological markers and mechanisms for predicting and explaining disease processes in terms of etiology and pathogenesis. Pathophysiology is formally considered as a subdiscipline within physiology.

Description

The fundamental aim of the domain of pathophysiology is to unravel the altered biological (i.e., physical and...

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References and Readings

  1. Cornier, M.-A., Dabelea, D., Hernandez, T. L., Lindstrom, R. C., Steig, A. J., Stob, N. R., et al. (2008). The metabolic syndrome. Endocrine Reviews, 29, 777–822.PubMedCrossRefGoogle Scholar
  2. Ehlert, U., Gaab, J., & Heinrichs, M. (2001). Psychoneuroendocrinological contributions to the etiology of depression, post-traumatic stress disorder, and stress related bodily disorders: The role of the hypothalamus-pituitary-adrenal axis. Biological Psychology, 57, 141–152.PubMedCrossRefGoogle Scholar
  3. Heim, C., Ehlert, U., & Hellhammer, D. H. (2000). The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders. Psychoneuroendocrinology, 25, 1–35.PubMedCrossRefGoogle Scholar
  4. Heim, C., Nater, U., Maloney, E., Boneva, R., Jones, J. F., & Reeves, W. C. (2009). Childhood trauma and risk for chronic fatigue syndrome. Archives of General Psychiatry, 66, 72–80.PubMedCrossRefGoogle Scholar
  5. Latremoliere, A., & Woolf, C. J. (2009). Central sensitization: A generator of pain hypersensitivity by central neural plasticity. The Journal of Pain, 10, 895–926.PubMedCrossRefGoogle Scholar
  6. Lautenbacher, S., & Fillingim, R. B. (2004). Pathophysiology of pain perception. New York, NY: Kluwer Academic/Plenum.CrossRefGoogle Scholar
  7. Müller, M., & Holsboer, F. (2004). Hormones, stress and depression. In C. Kordon, R.-C. Gaillard, & Y. Christen (Eds.), Hormones and the brain. Berlin, NY: Springer.Google Scholar
  8. Steptoe, A. (2010). Handbook of behavioral medicine – methods and application. New York: Springer.CrossRefGoogle Scholar
  9. Woolf, C. J. (2011). Central sensitization: Implications for the diagnosis and treatment of pain. Pain, 152, 2–15.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, New York 2013

Authors and Affiliations

  1. 1.Psychologisches Institut Abteilung Klinische Psychologie und PsychotherapieJohannes Gutenberg Universität MainzMainzGermany