Definition
Proteomics is the study of all of a genome’s putative proteins and involves the systematic analysis of proteins to determine their identity, quantity, and function (Soloviev, Barry, & Terrett, 2004).
Description
The Human Genome Project and related work have focused considerable attention on sequencing aspects of genomic research. However, as Holmes, Ramkissoon, & Giddings (2005) noted, “The eventual goal of these projects is actually to determine how the genome builds life through proteins. DNA has been the focus of attention because the tools for studying it are more advanced and because it is at the heart of the cell, carrying all the information – the blueprint – for life. However, a blueprint without a builder is not very useful, and the proteins are the primary builders within the cell.”
It is of interest to characterize the complement of expressed proteins from a single genome. Monitoring the expression and properties of a large number of proteins provides important...
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References and Readings
Augen, J. (2005). Bioinformatics in the post-genomic era: Genome, transcriptome, proteome, and information-based medicine. Boston: Addison-Wesley.
Holmes, M. R., Ramkissoon, K. R., & Giddings, M. C. (2005). Proteomics and protein identification. In A. D. Baxevanis & B. F. F. Ouellette (Eds.), Bioinformatics: A practical guide to the analysis of genes and proteins (3rd ed.). Hoboken, NJ: Wiley-Interscience.
Soloviev, M., Barry, R., & Terrett, J. (2004). Chip-based proteomics technology. In R. Rapley & S. Harbron (Eds.), Molecular analysis and genome discovery. Hoboken, NJ: Wiley.
Watson, J. D. (2004). DNA: The secret of life. New York: Alfred A Knopf.
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© 2013 Springer Science+Business Media, New York
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Turner, J.R. (2013). Proteomics. In: Gellman, M.D., Turner, J.R. (eds) Encyclopedia of Behavioral Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1005-9_1689
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DOI: https://doi.org/10.1007/978-1-4419-1005-9_1689
Publisher Name: Springer, New York, NY
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