Encyclopedia of Behavioral Medicine

2013 Edition
| Editors: Marc D. Gellman, J. Rick Turner

Principle of Equipoise

  • J. Rick Turner
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-1005-9_1052

Synonyms

Definition

Clinical equipoise exists when all of the available evidence about a new intervention/treatment does not show that it is more beneficial than an alternative and, equally, does not show that it is less beneficial than the alternative. For example, to be able to conduct a clinical trial that involves administering an investigational treatment that may confer therapeutic benefit to subjects for whom such benefit is desirable to some individuals, and to administer a control intervention treatment that is not capable of conferring therapeutic benefit to others, there cannot be any evidence that suggests that the investigational intervention shows greater efficacy than the control treatment or that it leads to greater side effects than the control treatment.

When individuals agree to participate in a clinical study, they do so with the understanding that all of the treatments are assumed to be of equal value. By the end of the trial, there...

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References and Readings

  1. Derenzo, E., & Moss, J. (2006). Writing clinical research protocols: Ethical considerations. San Diego: Elsevier.Google Scholar
  2. Turner, J. R. (2010). New drug development: An introduction to clinical trials. New York: Springer.Google Scholar

Copyright information

© Springer Science+Business Media, New York 2013

Authors and Affiliations

  1. 1.Cardiovascular SafetyQuintilesDurhamUSA