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Role of Combination Therapies in the Treatment of Non-small Cell Lung Cancer and Thoracic Metastasis

Reference work entry

Abstract

Lung cancer is the most common cancer worldwide, accounting for 1.3 million deaths annually. It is also a disease of the elderly, with 81 % of those living with lung cancer being ≥60 years of age, making them poor surgical candidates. Various alternative combined modalities are being investigated including limited resection with brachytherapy, RFA with conventional RT, and RFA with SBRT. This chapter reviews the basic principles underlying these promising combination therapies.

Keywords

Stereotactic Body Radiation Thermal Ablation Conventional Radiation Therapy Limited Resection Thermal Ablation Technique 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Horner MJ, et al. SEER Cancer statistics review, 1975–2006, National Cancer Institute. Bethesda. http://seer.cancer.gov/csr/1975_2006/, based on 2008 Nov SEER data submission, posted to the SEER web site, 2009.
  2. 2.
    Lloyd-Jones D, et al. Circulation. Heart disease and stroke statistics – 2010 update. A report from the American Heart Association. 2009 Dec 17.Google Scholar
  3. 3.
    Ginsberg RJ, et al. Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung cancer study group. Ann Thorac Surg. 1995;60(3):615–22; 622–3.CrossRefPubMedGoogle Scholar
  4. 4.
    Warram J. Preoperative irradiation of cancer of the lung: final report of a therapeutic trial. A collaborative study. Cancer. 1975;36(3):914–25.CrossRefPubMedGoogle Scholar
  5. 5.
    Kazem I, et al. Evaluation of short-course preoperative irradiation in the treatment of resectable bronchus carcinoma: long-term analysis of a randomized pilot-study. Int J Radiat Oncol Biol Phys. 1984;10(7):981–5.CrossRefPubMedGoogle Scholar
  6. 6.
    PORT Meta-analysis Trialists Group. Postoperative radiotherapy for non-small cell lung cancer. Cochrane Database Syst Rev. 2005;2:CD002142.Google Scholar
  7. 7.
    Douillard JY, et al. Impact of postoperative radiation therapy on survival in patients with complete resection and stage I, II, or IIIA non-small-cell lung cancer treated with adjuvant chemotherapy: the adjuvant Navelbine International Trialist Association (ANITA) randomized trial. Int J Radiat Oncol Biol Phys. 2008;72(3):695–701. Epub 2008 Apr 24.CrossRefPubMedGoogle Scholar
  8. 8.
    Machtay M, et al. Risk of death from intercurrent disease is not excessively increased by modern postoperative radiotherapy for high-risk resected non-smallcell lung carcinoma. J Clin Oncol. 2001;19(19):3912–7.CrossRefPubMedGoogle Scholar
  9. 9.
    Shennib H, et al. Video-assisted wedge resection and local radiotherapy for peripheral lung cancer in high-risk patients: the Cancer and Leukemia Group B (CALGB) 9335, a phase II, multi-institutional cooperative group study. J Thorac Cardiovasc Surg. 2005;129(4):813–8.CrossRefPubMedGoogle Scholar
  10. 10.
    Fernando HC, et al. Lobar and sublobar resection with and without brachytherapy for small stage IA non-small cell lung cancer. J Thorac Cardiovasc Surg. 2005;129(2):261–7.CrossRefPubMedGoogle Scholar
  11. 11.
    Strauss GM, et al. Adjuvant paclitaxel plus carboplatin compared with observation in stage IB non-small-cell lung cancer: CALGB 9633 with the cancer and leukemia group B, Radiation therapy oncology group, and north central cancer treatment group study groups. J Clin Oncol. 2008;26(31):5043–51. Epub 2008 Sep 22.CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Arriagada R, et al. Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer. N Engl J Med. 2004;350(4):351–60.CrossRefPubMedGoogle Scholar
  13. 13.
    Winton T, et al. Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer. N Engl J Med. 2005;352(25):2589–97.CrossRefPubMedGoogle Scholar
  14. 14.
    Waller D, et al. Chemotherapy for patients with non-small cell lung cancer: the surgical setting of the big lung trial. Eur J Cardiothorac Surg. 2004;26(1):173–82.CrossRefPubMedGoogle Scholar
  15. 15.
    Douillard JY, et al. Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected stage IB-IIIA non-small-cell lung cancer (Adjuvant Navelbine International Trialist Association [ANITA]): a randomised controlled trial. Lancet Oncol. 2006;7(9):719–27.CrossRefPubMedGoogle Scholar
  16. 16.
    Perry MC, et al. A phase III study of surgical resection and paclitaxel/carboplatin chemotherapy with or without adjuvant radiation therapy for resected stage III non-small-cell lung cancer: cancer and leukemia group B 9734. Clin Lung Cancer. 2007;8(4):268–72.CrossRefPubMedGoogle Scholar
  17. 17.
    Keller SM, et al. A randomized trial of postoperative adjuvant therapy in patients with completely resected stage II or IIIA non-small-cell lung cancer. Eastern cooperative oncology group. N Engl J Med. 2000;343(17):1217–22.CrossRefPubMedGoogle Scholar
  18. 18.
  19. 19.
    Janjan NA. Bone metastases: approaches to management. Semin Oncol. 2001;28:28–34.CrossRefPubMedGoogle Scholar
  20. 20.
    Janjan NA. Radiation for bone metastases: conventional techniques and the role of systemic radiopharmaceuticals. Cancer. 1997;80(suppl 5):1628–45.CrossRefPubMedGoogle Scholar
  21. 21.
    Dupuy DE, et al. Percutaneous radiofrequency ablation of painful osseous metastases: a multicenter American College of Radiology Imaging Network trial. Cancer. 2010;116(4):989–97.CrossRefPubMedPubMedCentralGoogle Scholar
  22. 22.
    Gandhi S, et al. Combined computed tomography-guided radiofrequency ablation and brachytherapy in a child with multiple recurrences of Wilms’ tumor. J Pediatr Hematol Oncol. 2005;27:377–9.CrossRefPubMedGoogle Scholar
  23. 23.
    Seegenschmiedt MH, Brady LW, Sauer R. Interstitial thermoradiotherapy: review on technical and clinical aspects. Am J Clin Oncol. 1990;13:352–63.CrossRefPubMedGoogle Scholar
  24. 24.
    Trembley BS, Ryan TP, Strohbehn JW. Interstitial hyperthermia: physics, biology and clinical aspects. In: Urano M, Douple E, editors. Physics of microwave hyperthermia in hyperthermia and oncology, vol. 3. Utrecht: Springer; 1992. p. 11–98.Google Scholar
  25. 25.
    Dupuy D, DiPetrillo T, Gandhi S, Ready N, Ng T, Donat W, Mayo-Smith W. Radiofrequency ablation followed by conventional radiotherapy for medically inoperable stage I non-small cell lung cancer. Chest. 2006;129:738–45.CrossRefPubMedGoogle Scholar
  26. 26.
    Grieco CA, Simon CJ, Mayo-Smith WW, DiPetrillo TA, Ready N, Dupuy D. Percutaneous image-guided thermal ablation and radiation therapy: outcomes of combined treatment for 41 patients with inoperable stage I/II non-small-cell lung cancer. J Vasc Interv Radiol. 2006;17:1117–24.CrossRefPubMedGoogle Scholar
  27. 27.
    Simon CJ, Dupuy DE, Mayo-Smith WW. Microwave ablation: principles and applications. Radiographics. 2005;25(suppl):69–83.CrossRefGoogle Scholar
  28. 28.
    Kupelian PA, et al. Prognostic factors in the treatment of node-negative non-small cell lung carcinoma with radiotherapy alone. Int J Radiat Oncol Biol Phys. 1996;36:607–13.CrossRefPubMedGoogle Scholar
  29. 29.
    Rowell NP, et al. Radical radiotherapy for stage I/II non-small cell lung cancer in patients not sufficiently fit for or declining surgery (medically inoperable): a systematic review. Thorax. 2001;56:628–38.CrossRefPubMedPubMedCentralGoogle Scholar
  30. 30.
    McGarry RC, et al. Observation-only management of early stage, medically inoperable lung cancer: poor outcome. Chest. 2002;121:1155–8.CrossRefPubMedGoogle Scholar
  31. 31.
    Senan S, Lagerwaard FJ. The role of radiotherapy in non-small-cell lung cancer. Ann Oncol. 2005;16(Suppl 2):223–8.Google Scholar
  32. 32.
    Lee W, Daly BDT, DiPetrillo TA, et al. Limited resection for non-small cell lung cancer; observed local control with implantation of I-125 brachytherapy seeds. Ann Thorac Surg. 2003;75:237–43.CrossRefPubMedGoogle Scholar
  33. 33.
    Jain SK, Dupuy DE, Cardarelli GA, et al. Percutaneous radiofrequency ablation of pulmonary malignancies: combined treatment with brachytherapy. AJR Am J Roentgenol. 2003;181:711–5.CrossRefPubMedGoogle Scholar
  34. 34.
    Timmerman R, et al. Excessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer. J Clin Oncol. 2006;24(30):4833–9.CrossRefPubMedGoogle Scholar
  35. 35.
    Hoopes DJ, et al. FDG-PET and stereotactic body radiotherapy (SBRT) for stage I non-small-cell lung cancer. Lung Cancer. 2007;56(2):229–34. Epub 2007 Mar 13.CrossRefPubMedGoogle Scholar
  36. 36.
    Onishi H, et al. Hypofractionated stereotactic radiotherapy (HypoFXSRT) for stage I non-small cell lung cancer: updated results of 257 patients in a Japanese multi-institutional study. J Thorac Oncol. 2007;2(7 Suppl 3):S94–100.CrossRefPubMedGoogle Scholar
  37. 37.
    Haasbeek CJ, et al. Stage I nonsmall cell lung cancer in patients aged >/=75 years: outcomes after stereotactic radiotherapy. Cancer. 2010;116(2):406–14.CrossRefPubMedGoogle Scholar
  38. 38.
    Lo SS, et al. Stereotactic body radiation therapy for oligometastases. Expert Rev Anticancer Ther. 2009;9(5):621–35.CrossRefPubMedGoogle Scholar
  39. 39.
    Kapp DS, Cox RS. Thermal treatment parameters are most predictive of outcome in patients with single tumor nodules per treatment field in recurrent adenocarcinoma of the breast. Int J Radiat Oncol Biol Phys. 1995;33:887–99.CrossRefPubMedGoogle Scholar
  40. 40.
    Kapp DS, Lawrence R. Temperature elevation during brachytherapy for carcinoma of the uterine cervix: adverse effect on survival and enhancement of distant metastasis. Int J Radiat Oncol Biol Phys. 1984;10:2281–92.CrossRefPubMedGoogle Scholar
  41. 41.
    Berdov BA, Menteshashvili GZ. Thermoradiotherapy of patients with locally advanced carcinoma of the rectum. Int J Hyperthermia. 1990;6:881–90.CrossRefPubMedGoogle Scholar
  42. 42.
    Datta NR, Bose AK, Kapoor HK, et al. Head and neck cancers: results of thermoradiotherapy versus radiotherapy. Int J Hyperthermia. 1990;6:479–86.CrossRefPubMedGoogle Scholar
  43. 43.
    Dewey WC. Arrhenius relationships from the molecule and cell to the clinic. Int J Hyperthermia. 1994;10:457–83.CrossRefPubMedGoogle Scholar
  44. 44.
    Franckena M, et al. Long-term improvement in treatment outcome after radiotherapy and hyperthermia in locoregionally advanced cervix cancer: an update of the dutch deep hyperthermia trial. Int J Radiat Oncol Biol Phys. 2008;70(4):1176–82.CrossRefPubMedGoogle Scholar
  45. 45.
    Wust P, et al. Hyperthermia in combined treatment of cancer. Lancet Oncol. 2002;3:487–97.CrossRefPubMedGoogle Scholar
  46. 46.
    Horkan C, et al. Reduced tumor growth with combined radiofrequency ablation and radiation therapy in a rat breast tumor model. Radiology. 2005;235:81–8.CrossRefPubMedGoogle Scholar
  47. 47.
    Kocak Z, Evans ES, Zhou SM, et al. Challenges in defining radiation pneumonitis in patients with lung cancer. Int J Radiat Oncol Biol Phys. 2005;623:635–8.CrossRefGoogle Scholar
  48. 48.
    Steinke K, Sewell PE, Dupuy DE. Pulmonary radiofrequency ablation: an international study survey. Anticancer Res. 2004;24:339–43.PubMedGoogle Scholar
  49. 49.
    Steinke K, King J, Glenn D, et al. Percutaneous radiofrequency ablation of lung tumors with expandable needle electrodes: tips from preliminary experience. AJR Am J Roentgenol. 2004;183:605–11.CrossRefPubMedGoogle Scholar
  50. 50.
    Lee JM, Jin GY, Goldberg SN, et al. Percutaneous radiofrequency ablation for inoperable non-small cell lung cancer and metastases: preliminary report. Radiology. 2004;230:125–34.CrossRefPubMedGoogle Scholar
  51. 51.
    Akeboshi M, Yamakado K, Nakatsuka A, et al. Percutaneous radiofrequency ablation of lung neoplasms: initial therapeutic response. J Vasc Interv Radiol. 2004;15:463–70.CrossRefPubMedGoogle Scholar
  52. 52.
    Kotaro Y, Susumu K, Yoshifumi S, et al. Thoracic tumors treated with CT-guided radiofrequency ablation: initial experience. Radiology. 2004;231:850–7.CrossRefGoogle Scholar
  53. 53.
    Cosmo G, Vittorio M, Giuseppe C, et al. Radiofrequency ablation of 40 lung neoplasms: preliminary results. AJR Am J Roentgenol. 2004;183:361–8.CrossRefGoogle Scholar
  54. 54.
    Cox JE, Chiles C, McManus CM, et al. Transthoracic needle aspiration biopsy: variables that affect risk of pneumothorax. Radiology. 1999;212:165–8.CrossRefPubMedGoogle Scholar
  55. 55.
    Yamamoto A, Matsuoka T, Toyoshima M, et al. Assessment of cerebral microembolism during percutaneous radiofrequency ablation of lung tumors using diffusion weighted imaging. Am J Roentgenol. 2004;183:1785–9.CrossRefGoogle Scholar
  56. 56.
    Parashar B, et al. Limited resection followed by intraoperative seed implantation is comparable to stereotactic body radiotherapy for solitary lung cancer. Cancer. 2010;116(21):5047–53.CrossRefPubMedGoogle Scholar
  57. 57.
    Abbas G, et al. Ablative treatments for lung tumors: radiofrequency ablation, stereotactic radiosurgery, and microwave ablation. Thorac Surg Clin. 2007 May;17(2):261–71.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Radiation OncologyUniversity of Pittsburgh Medical Center- Regional Cancer CenterJohnstownUSA
  2. 2.Department of Diagnostic Imaging, Rhode Island HospitalThe Warren Alpert Medical School of Brown UniversityProvidenceUSA

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