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11C: Labeling Chemistry and Labeled Compounds

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Handbook of Nuclear Chemistry

Abstract

Methods for the synthesis of compounds labeled with the short-lived positron emitting radionuclide 11C are described. Important aspects on how to achieve high specific radioactivity and the need for technical solutions to establish a reproducible routine tracer production are pointed out. Examples of positron emission tomography (PET) as a tool in drug development are also included.

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Authors and Affiliations

  1. Uppsala University, Uppsala Imanet AB, P.O. Box 967, S-751 09, Uppsala, Sweden

    G. Antoni & T. Kihlberg

  2. Department of Biochemistry and Organic Chemistry, Uppsala University, Uppsala Imanet AB, P.O. Box 967, S-751 09, Uppsala, Sweden

    B. Långström

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  1. G. Antoni
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  2. T. Kihlberg
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  3. B. Långström
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Correspondence to G. Antoni .

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Editors and Affiliations

  1. Institute of Chemistry, Eötvös Loránd University, 32, Budapest, 1518, Hungary

    Attila Vértes (Professor Emeritus) & Sándor Nagy (Professor) (Professor Emeritus) &  (Professor)

  2. Chemical Research Center, Hungarian Academy of Sciences, Pusztaszeri út 59-67, Budapest, 1025, Hungary

    Zoltán Klencsár (Dr.) (Dr.)

  3. Institute of Nuclear Research (ATOMKI), Hungarian Academy of Sciences, 51, Debrecen, 4001, Hungary

    Rezső G. Lovas (Professor) (Professor)

  4. Institute of Nuclear Chemistry, Johannes Gutenberg University Mainz, Fritz-Strassmann-Weg 2, 55128, Mainz, Germany

    Frank Rösch (Professor) (Professor)

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Antoni, G., Kihlberg, T., Långström, B. (2011). 11C: Labeling Chemistry and Labeled Compounds. In: Vértes, A., Nagy, S., Klencsár, Z., Lovas, R.G., Rösch, F. (eds) Handbook of Nuclear Chemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0720-2_41

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