Radionuclide Generators

  • F. Rösch
  • F. F. KnappJr


Radionuclide generator systems continue to play a key role in providing both diagnostic and therapeutic radionuclides for various applications in nuclear medicine, oncology, and interventional cardiology. Although many parent/daughter pairs have been evaluated as radionuclide generator systems, there are a relatively small number of generators, which are currently in routine clinical and research use. Essentially every conceivable approach has been used for parent/separation strategies, including sublimation, thermochromatographic separation, solvent extraction, and adsorptive column chromatography. The most widely used radionuclide generator for clinical applications is the 99Mo/99mTc generator system, but recent years have seen an enormous increase in the use of generators to provide therapeutic radionuclides, which has paralleled the development of complementary technologies for targeting agents for therapy and in the general increased interest in the use of unsealed therapeutic radioactive sources. More recently, use of the 68Ge/68Ga generator is showing great potential as a source of positron-emitting 68Ga for positron emission tomography (PET)/CT imaging. Key advantages for the use of radionuclide generators include reasonable costs, the convenience of obtaining the desired daughter radionuclide on demand, and availability of the daughter radionuclide in high specific activity, no-carrier added form.


Positron Emission Tomography Decay Chain Radionuclidic Purity Single Photon Emission Computer Tomography Daughter Nuclide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors thank their many colleagues and collaborators for their support and interest. Research at the Oak Ridge National Laboratory (ORNL) supported by the US Department of Energy (DOE), under contract DE-AC05-00OR22725 with UT-Battelle, LLC.


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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • F. Rösch
    • 1
  • F. F. KnappJr
    • 2
  1. 1.Institute of Nuclear ChemistryJohannes Gutenberg-University MainzMainzGermany
  2. 2.Nuclear Medicine ProgramNuclear Science and Technology Division, Oak Ridge National LaboratoryOak RidgeUSA

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