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Isotope Effects

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Handbook of Nuclear Chemistry

Abstract

Isotope effects, that is, differences brought about by isotopic substitution in the physical and chemical properties of atoms and molecules, are reviewed from the point of view of spectroscopy, chemical equilibria, phase equilibria, physicochemical properties, reaction kinetics, and biology. The theory of isotope effects is discussed in some detail.

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References

  • Arnett EM, McKelvey DR (1969) In: Coetzee JF, Ritchie CD (eds) Solute-solvent interactions, Chapter 6. Marcel Dekker, New York, pp 344–398

    Google Scholar 

  • Bacsik Z, Canongia Lopes JN, Costa Gomes MF, Jancsó G, Mink J, Pádua AAH (2002) J Chem Phys 116:10816

    CAS  Google Scholar 

  • Bartell LS, Roskos RR (1966) J Chem Phys 44:457

    CAS  Google Scholar 

  • Bell RP (1980) The tunnel effect in chemistry. Chapman and Hall, London

    Google Scholar 

  • Bigeleisen J (1949) J Chem Phys 17:675

    CAS  Google Scholar 

  • Bigeleisen J (1955) J Chem Phys 23:2264

    CAS  Google Scholar 

  • Bigeleisen J (1961a) J Chem Phys 34:1485

    CAS  Google Scholar 

  • Bigeleisen J (1961b) In: London H (ed) Separation of isotopes, Chapter 5. George Newnes, London, pp 95–122

    Google Scholar 

  • Bigeleisen J (1975) ACS Symp Ser 11:1

    CAS  Google Scholar 

  • Bigeleisen J (1984) J Chem Educ 61:108

    CAS  Google Scholar 

  • Bigeleisen J (1996a) Proc Natl Acad Sci USA 93:9393

    CAS  Google Scholar 

  • Bigeleisen J (1996b) J Am Chem Soc 118:3676

    CAS  Google Scholar 

  • Bigeleisen J, Mayer MG (1947) J Chem Phys 15:261

    CAS  Google Scholar 

  • Bigeleisen J, Wolfsberg M (1958) Adv Chem Phys 1:15

    CAS  Google Scholar 

  • Bigeleisen J, Lee MW, Mandel F (1973) Ann Rev Phys Chem 24:407

    CAS  Google Scholar 

  • Brodsky AE (1961) Isotopenchemie. Akademie-Verlag, Berlin

    Google Scholar 

  • Bruner F, Cartoni GP, Liberti A (1966) Anal Chem 38:298

    CAS  Google Scholar 

  • Buchachenko AI (2001) J Phys Chem A 105:9995

    CAS  Google Scholar 

  • Buchachenko AI, Galimov EM, Nikiforov GA (1976) Dokl Akad Nauk SSSR 228:379

    CAS  Google Scholar 

  • Buckingham AD, Fan-Chen L (1981) Int Rev Phys Chem 1:253

    CAS  Google Scholar 

  • Buddenbaum WE, Shiner VJ Jr (1977) In: Cleland WW, O’Leary MH, Northrop DB (eds) Isotope effects on enzyme-catalyzed reactions. University Park Press, Baltimore, pp 1–36

    Google Scholar 

  • Chen W, Orna MV (1996) J Chem Educ 73:485

    CAS  Google Scholar 

  • Cho CH, Urquidi J, Singh S, Robinson GW (1999) J Phys Chem B 103:1991

    CAS  Google Scholar 

  • Cleland WW, O’Leary MH, Northrop DB (eds) (1977) Isotope effects on enzyme-catalyzed reactions. University Park Press, Baltimore

    Google Scholar 

  • Collins NS, Bowman S (eds) (1971) Isotope effects in chemical reactions. Van Nostrand Reinhold, New York

    Google Scholar 

  • Conway BE (1981) Ionic hydration in chemistry and biophysics, Chapter 26. Elsevier, Amsterdam, pp 551–568

    Google Scholar 

  • Craig H, Miller SL, Wasserburg GJ (eds) (1964) Isotope and cosmic chemistry. North-Holland, Amsterdam

    Google Scholar 

  • Criss RE (1999) Principles of stable isotope distribution. Oxford University Press, Oxford

    Google Scholar 

  • Čuma M, Scheiner S (1997) J Phys Org Chem 10:383

    Google Scholar 

  • Dang LX, Bopp P, Wolfsberg M (1989) Z Naturforsch 44a:485

    Google Scholar 

  • Dembiński W, Poniński M, Fiedler R (1998) Separ Sci Technol 33:1693

    Google Scholar 

  • Dezentje RFR, Dekkers HPJM (1976) Chem Phys 18:189

    CAS  Google Scholar 

  • Estep MF, Hoering TC (1980) Geochim Cosmochim Acta 44:1197

    CAS  Google Scholar 

  • Estep MF, Hoering TC (1981) Plant Physiol 67:474

    CAS  Google Scholar 

  • Fenby DV, Kooner ZS, Khurma JR (1981) Fluid Phase Equilib 7:327

    CAS  Google Scholar 

  • Filer CN (1999) J Labelled Compd Rad 42:169

    CAS  Google Scholar 

  • Förstel H (1978) Report Jül-1539, Kernforschungsanlage Jülich GmbH, Jülich

    Google Scholar 

  • Francisco WA, Knapp MJ, Blackburn NJ, Klinman JP (2002) J Am Chem Soc 124:8194

    CAS  Google Scholar 

  • Fujii Y, Nomura M, Okamoto M, Onitsuka H, Kawakami F, Takeda K (1989) Z Naturforsch 44a:395

    Google Scholar 

  • Fusch CH, Spririg N, Moeller H (1993) Eur J Clin Chem Clin Biochem 31:639

    CAS  Google Scholar 

  • Gao YQ, Marcus RA (2001) Science 293:259

    CAS  Google Scholar 

  • Gao YQ, Marcus RA (2002) J Chem Phys 116:137

    CAS  Google Scholar 

  • Gao YQ, Chen WC, Marcus RA (2002) J Chem Phys 117:1536

    CAS  Google Scholar 

  • Gebauer G, Förstel H, Rating D (eds) (1993) In: Proceedings of the annual meeting of Arbeitsgemeinschaft stabile isotope e.V., Isotopenpraxis Environmental and Health Studies, vol 29, pp 3–198

    Google Scholar 

  • Glasoe PK, Long FA (1960) J Phys Chem 64:188

    CAS  Google Scholar 

  • Harvey AH, Lemmon EW (2002) J Phys Chem Ref Data 31:173

    CAS  Google Scholar 

  • Ivlev AA (2001) Separ Sci Technol 36:1819

    CAS  Google Scholar 

  • Jancsó G (2002) Nukleonika 47(suppl 1):53

    Google Scholar 

  • Jancsó G, Van Hook WA (1974) Chem Rev 74:689

    Google Scholar 

  • Jancsó G, Rebelo LP, Van Hook WA (1993) Chem Rev 93:2645

    Google Scholar 

  • Jancsó G, Rebelo LP, Van Hook WA (1994) Chem Soc Rev 93:257

    Google Scholar 

  • Janssen C, Guenther J, Mauersberger K, Krankowsky D (2001) Phys Chem Chem Phys 3:4718

    CAS  Google Scholar 

  • Jones PJH, Leatherdale ST (1991) Clin Sci 80:277

    CAS  Google Scholar 

  • Katz JJ, Crespi HL (1971) In: Collins CL, Bowman NS (eds) Isotope effects in chemical reactions, Chapter 5. Van Nostrand Reinhold, New York, pp 286–363

    Google Scholar 

  • Katz JJ, Uphaus RA, Crespi HL, Blake MI (1975) ACS Symp Ser 11:184

    CAS  Google Scholar 

  • Kim DW, Jeon YS, Eom TY, Suh MY, Lee CH (1991) J Radioanal Nucl Chem 150:417

    CAS  Google Scholar 

  • Kleinman LI, Wolfsberg M (1973) J Chem Phys 59:2043

    CAS  Google Scholar 

  • Kleinman LI, Wolfsberg M (1974) J Chem Phys 60:4749

    CAS  Google Scholar 

  • Knapp MJ, Rickert K, Klinman JP (2002) J Am Chem Soc 124:3865

    CAS  Google Scholar 

  • Knyazev AD, Myasoedov NF (2001) Separ Sci Technol 36:1677

    CAS  Google Scholar 

  • Knyazev DA, Semin GK, Bochkarev AV (1999) Polyhedron 18(20):2579

    CAS  Google Scholar 

  • Knyazev DA, Bochkarev AV, Myasoedov NF (2001) Separ Sci Technol 36:1595

    CAS  Google Scholar 

  • Krankowsky D, Mauersberger K (1996) Science 274:1324

    CAS  Google Scholar 

  • Kresge AJ (1977) In: Cleland WW, O’Leary MH, Northrop DB (eds) Isotope effects on enzyme-catalyzed reactions. University Park Press, Baltimore, pp 37–63

    Google Scholar 

  • Krumbiegel P (1970) Isotopieeffekte. Akademie-Verlag, Berlin

    Google Scholar 

  • Krumbiegel P (1991) Stable isotope pharmaceuticals for clinical research and diagnosis. Gustav Fischer Verlag, Jena

    Google Scholar 

  • Lacks DJ (1995) J Chem Phys 103:5085

    CAS  Google Scholar 

  • Laughton PM, Robertson RE (1969) In: Coetzee JF, Ritchie CD (eds) Solute-solvent interactions, Chapter 7. Marcel Dekker, New York, pp 399–538

    Google Scholar 

  • Lee DA (1969) Adv Chem Ser 89:57

    Google Scholar 

  • Mauersberger K, Lämmerzahl P, Krankowsky D (2001) Geophys Res Lett 28:3155

    CAS  Google Scholar 

  • Melander L (1960) Isotope effects on reaction rates. Ronald Press, New York

    Google Scholar 

  • Melander L, Saunders WH (1980) Reaction rates of isotopic molecules. Wiley, New York

    Google Scholar 

  • Menes F, Dorfmüller T, Bigeleisen J (1970) J Chem Phys 53:2869

    CAS  Google Scholar 

  • Mioduski T (1999) Comments Inorg Chem 21:175

    CAS  Google Scholar 

  • Müller G, Mauersberger K, Sprinz H (1969) Analyse stabiler isotope durch spezielle Methoden. Akademie-Verlag, Berlin

    Google Scholar 

  • Nash CP (1975) ACS Symp Ser 11:29

    CAS  Google Scholar 

  • O’Leary MH (1981) Phytochemistry 20:553

    Google Scholar 

  • Polavarapu PL, Nafle LA, Benner SA, Morton TH (1981) J Am Chem Soc 103:5349

    CAS  Google Scholar 

  • Rabinovich IB (1960) Usp Khim 31:101

    Google Scholar 

  • Rabinovich IB (1970) Influence of isotopy on the physicochemical properties of liquids. Consultants Bureau, New York

    Google Scholar 

  • Rae HK (ed) (1978) Separation of hydrogen isotopes, ACS Symp Ser 68. American Chemical Society, Washington

    Google Scholar 

  • Richet P, Bottinga Y, Javoy M (1977) Ann Rev Earth Planet Sci 5:65

    CAS  Google Scholar 

  • Rittenberg D (1964) In: Craig H, Miller SL, Wasserburg GJ (eds) Isotope and cosmic chemistry, Chapter 6. North-Holland, Amsterdam, pp 60–69

    Google Scholar 

  • Roginski SS (1962) Theoretische Grundlagen der Isotopenchemie. VEB Deutscher Verlag d. Wissenschaften, Berlin

    Google Scholar 

  • Rundel PW, Ehleringer JR, Nagy KA (eds) (1988) Stable isotopes in ecological research. Springer, New York

    Google Scholar 

  • Schatenstein AI (1960) Isotopenanalyse des Wassers. VEB Deutscher Verlag d. Wissenschaften, Berlin

    Google Scholar 

  • Schön W, Wiechers R, Woermann D (1986) J Chem Phys 85:2922

    Google Scholar 

  • Schowen RL (1977) In: Cleland WW, O’Leary MH, Northrop DB (eds) Isotope effects on enzyme-catalyzed reactions. University Park Press, Baltimore, pp 64–99

    Google Scholar 

  • Shiner VJ Jr (1975) ACS Symp Ser 11:163

    CAS  Google Scholar 

  • Sims LB, Lewis DE (1984) In: Buncel E, Lee CC (eds) Isotope effects: recent developments in theory and experiment, Chapter 4. Elsevier, Amsterdam, pp 161–259

    Google Scholar 

  • Singh RR, Van Hook WA (1987) J Chem Phys 87:6097

    CAS  Google Scholar 

  • Smith BN, Epstein S (1970) Plant Physiol 46:738

    CAS  Google Scholar 

  • Somlyai G, Jancsó G, Jákli GY, Vass K, Barna B, Lakics V, Gaál T (1993) FEBS Lett 317:1

    CAS  Google Scholar 

  • Sponheimer M, Lee-Thorp JA (1999) Science 283:368

    CAS  Google Scholar 

  • Stern MJ, Van Hook WA, Wolfsberg M (1963) J Chem Phys 39:3179

    CAS  Google Scholar 

  • Stern MJ, Spindel W, Monse EU (1968) J Chem Phys 48:2908

    CAS  Google Scholar 

  • Syrett PJ (1961) In: London H (ed) Separation of isotopes, Chapter 13. George Newnes, London, pp 416–428

    Google Scholar 

  • Thiemens MH, Heidenreich JE III (1983) Science 219:1073

    CAS  Google Scholar 

  • Thomson JF (1963) Biological effects of deuterium. Pergamon, Oxford

    Google Scholar 

  • Turro NJ, Kraeutler B (1984) In: Buncel E, Lee CC (eds) Isotope effects: recent developments in theory and experiment, Chapter 3. Elsevier, Amsterdam, pp 107–160

    Google Scholar 

  • Urey HC (1947) J Chem Soc 562

    Google Scholar 

  • Urey HC, Greiff LJ (1935) J Am Chem Soc 57:321

    CAS  Google Scholar 

  • Urey HC, Brickwedde FG, Murphy GM (1932) Phys Rev 40:1

    CAS  Google Scholar 

  • Van Hook WA (1968) Isotopenpraxis 4:161

    Google Scholar 

  • Van Hook WA (1969) Adv Chem Ser 89:99

    Google Scholar 

  • Van Hook WA (1971) In: Collins CL, Bowman NS (eds) Isotope effects in chemical reactions, Chapter 1. Van Nostrand Reinhold, New York, pp 1–89

    Google Scholar 

  • Van Hook WA (1972a) J Phys Chem 76:3040

    Google Scholar 

  • Van Hook WA (1972b) J Chem Soc Chem Comm 479

    Google Scholar 

  • Van Hook WA (1975) ACS Symp Ser 11:101

    Google Scholar 

  • Van Hook WA (1994) Z Naturforsch 50a:337

    Google Scholar 

  • Vedamuthu M, Singh S, Robinson GW (1996) J Phys Chem 100:3825

    CAS  Google Scholar 

  • Vértes A, Kiss I (1987) Nuclear chemistry, Chapter 10. Akadémiai Kiadó, Budapest

    Google Scholar 

  • Vogel JC, Grootes PM, Mook WG (1970) Z Physik 230:225

    CAS  Google Scholar 

  • Vojta G (1960) Kernenergie 3:917

    CAS  Google Scholar 

  • Vojta G (1962) In: Hertz G (ed) Lehrbuch der Kernphysik, Band III, Chapter C. B. G. Teubner Verlagsgesellschaft, Leipzig, pp 88–116

    Google Scholar 

  • Weston RE Jr (1975) ACS Symp Ser 11:29

    Google Scholar 

  • Weston RE Jr (1999) Chem Rev 99:2115

    CAS  Google Scholar 

  • Willi AV (1983) Isotopeneffekte bei chemischen Reaktionen. Georg Thieme Verlag, Stuttgart

    Google Scholar 

  • Wolfsberg M (1969a) Adv Chem Ser 89:185

    Google Scholar 

  • Wolfsberg M (1969b) J Chem Phys 50:1484

    CAS  Google Scholar 

  • Wolfsberg M (1969c) Ann Rev Phys Chem 20:449

    CAS  Google Scholar 

  • Wolfsberg M (1972) Accounts Chem Res 5:225

    CAS  Google Scholar 

  • Wolfsberg M, Stern MJ (1964) Pure Appl Chem 8:225

    CAS  Google Scholar 

  • Zarzycki R, Chmielewski AG, Zakrzewska-Trznadel G (eds) (2002) Stable isotopes – some new fields of application. Polish Academy of Sciences, Łódź

    Google Scholar 

  • Ziegler H (1989) In: Rundel PW, Ehleringer JR, Nagy KA (eds) Stable isotopes in ecological research, Chapter 8. Springer, New York, pp 105–123

    Google Scholar 

  • Ziegler H, Osmond CB, Stichler W, Trimborn P (1976) Planta (Berl) 128:85

    CAS  Google Scholar 

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Jancsó, G. (2011). Isotope Effects. In: Vértes, A., Nagy, S., Klencsár, Z., Lovas, R.G., Rösch, F. (eds) Handbook of Nuclear Chemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0720-2_15

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