Reference work entry


AKT, also known as protein kinase B and RAC-PK, was first discovered as an oncogene transduced by the acute transforming retrovirus (AKT-8), which is known to cause leukemia in mice. AKT is the major downstream target of phosphatidylinositol 3-kinase (PI3K), which can be activated by receptor tyrosine kinases in response to various growth factors. AKT is a serine/threonine kinase located at the apex of a cascade of signaling pathways. Deregulated AKT signaling is implicated in cancer cell growth, proliferation, and survival. Novel antitumor strategies have now been developed to target AKT and key downstream targets in the clinic.


AKT A-443654 Assessment AT13148 AT7867 CCT128930 GSK690693 Predictive biomarkers Therapeutics Fluorescence in situ hybridization (FISH) Phosphatidylinositol 3-kinase (PI3K) Protein kinase B. See AKT 


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Drug Development Unit, Royal Marsden NHS Foundation Trust, and The Institute of Cancer ResearchSuttonUK

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