Premalignant and Malignant Tumors of the Vulva

  • Edward J. WilkinsonEmail author
Reference work entry


(Vulvar Squamous Intraepithelial Lesion, Dysplasia, Carcinoma In Situ)

The incidence of vulvar intraepithelial neoplasia (VIN) (dysplasia, carcinoma in situ) has nearly doubled when comparing recorded cases between 1973–1976 and 1985–1986 and is becoming more frequent in young women 20–35 years of age (30, [87]). The true incidence of VIN probably is higher, because generally only a subset, carcinoma in situ (VIN 3) cases, is reported. Approximately 50% of these women have other neoplasia involving the genital tract, most often cervical intraepithelial neoplasia (CIN). Approximately one half of these women have a history of a preexisting or concomitant sexually transmitted disease, of which condylomata acuminata is the most frequent. There is an association between VIN and cigarette smoking. Most patients are symptomatic, often with pruritus. Current terminology for squamous intraepithelial lesions (dysplasia, carcinoma in situ, vulvar intraepithelial neoplasia (VIN), as proposed by the World Health Organization [WHO]) is summarized in Table 2.1 [175]. Lesions of the vulva that are pigmented and papular or verrucoid have been clinically termed bowenoid papulosis by some authors [166], but they are histologically indistinguishable from other forms of intraepithelial neoplasia and behave in a similar fashion. The separate term bowenoid papulosis therefore is not included in the WHO classification.


Condyloma Acuminatum Lichen Sclerosus Verrucous Carcinoma Invasive Squamous Cell Carcinoma Paget Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Pathology, Division of Anatomic PathologyUniversity of Florida College of MedicineGainesvilleUSA

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