Germ Cell Tumors of the Ovary

  • Aleksander TalermanEmail author
  • Russell Vang
Reference work entry


Germ cell tumors are composed of a number of histologically different tumor types derived from the primitive germ cells of the embryonic gonad. The concept of germ cell tumors as a specific group of gonadal neoplasms has evolved over the last several decades. It is based on (1) the common histogenesis of these neoplasms, (2) the relatively frequent presence of histologically different neoplastic elements within the same tumor, (3) the presence of histologically similar neoplasms in extragonadal locations along the line of migration of the primitive germ cells from the wall of the yolk sac to the gonadal ridge [253], and (4) the remarkable homology between the various tumors in the male and the female. In no other group of gonadal neoplasms is this homology better illustrated. Although the strong morphologic resemblance between the testicular seminoma and its ovarian counterpart, the dysgerminoma was noted soon after these neoplasms were first described, for a long time there was no agreement as to their histogenesis. Nevertheless, these were the first neoplasms to become accepted as originating from germ cells. It was not until the studies by Teilum [231, 232] on the homology of ovarian and testicular neoplasms, the studies by Friedman and Moore [59] and Dixon and Moore [50] on testicular tumors, and those by Friedman [58] on related extragonadal neoplasms that the germ cell origin of other neoplasms belonging to this group was proposed. These views were supported by the embryologic studies of Witschi [253] and Gillman [66], and later by the experimental work of Stevens [200, 201, 202] and Pierce et al [149, 151] on germ cell tumors in rodents.


Germ Cell Tumor Embryonal Carcinoma Immature Teratoma Mature Cystic Teratoma Struma Ovarii 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Abbot TM, Herman WJ Jr, Scully RE (1984) Ovarian fetiform teratoma (homunculus) in a 9-year-old girl. Int J Gynecol Pathol 2:392CrossRefGoogle Scholar
  2. 2.
    Alenghat E, Okagaki T, Talerman A (1986) Primary mucinous carcinoid tumor of the ovary. Cancer (Phila) 58:777CrossRefGoogle Scholar
  3. 3.
    Allard S, Cadotte M, Boivin Y (1972) Dysgenesie gonadique pure familiale et gonadoblastome. Union Med Can 101:448–452PubMedGoogle Scholar
  4. 4.
    Anderson CT Jr, Carlson IH (1975) Elevated plasma testosterone and gonadal tumors in two 46XY “sisters”. Arch Pathol 99:360PubMedGoogle Scholar
  5. 5.
    Anderson MC, McDicken IW (1971) Melanotic cyst of the ovary. J Obstet Gynaecol Br Commonw 78:1047PubMedCrossRefGoogle Scholar
  6. 6.
    Arhelger RB, Kelly B (1974) Strumal carcinoid. Report of a case with electron microscopical observations. Arch Pathol 97:323PubMedGoogle Scholar
  7. 7.
    Arroyo JG, Harris W, Laden SA (1998) Recurrent mixed germ cell-sex cord-stromal tumor of the ovary in an adult. Int J Gynecol Pathol 17:281PubMedCrossRefGoogle Scholar
  8. 8.
    Arroyo MR, Podda A, Cao D et al (2009) Placental site trophoblastic tumor in the ovary of a young child with isosexual precocious puberty. Pediatr Dev Pathol 12:73PubMedCrossRefGoogle Scholar
  9. 9.
    Asadourian LA, Taylor HB (1969) Dysgerminoma. An analysis of 105 cases. Obstet Gynecol 33:370PubMedGoogle Scholar
  10. 10.
    Atkin NB (1973) High chromosome numbers of seminomata and malignant teratomata of the testis: a review of data on 103 tumors. Br J Cancer 28:275PubMedCrossRefGoogle Scholar
  11. 11.
    Atkin NB, Baker MC (1983) i(12p): specific chromosomal marker in seminoma and malignant teratoma of the testis? Cancer Genet Cytogenet 10:199PubMedCrossRefGoogle Scholar
  12. 12.
    Atkin NB, Baker MC (1987) Abnormal chromosomes including small metacentrics in 14 ovarian cancers. Cancer Genet Cytogenet 26:355PubMedCrossRefGoogle Scholar
  13. 13.
    Ayhan A, Bukulmez O, Genc C, Kuramursel BS, Ayhan A (2000) Mature cystic teratomas of the ovary. A case series from one institution over 34 years. Eur J Obstet Gynecol 88:153CrossRefGoogle Scholar
  14. 14.
    Baergen RN, Rutgers J, Young RH (2003) Extrauterine lesions of intermediate trophoblast. Int J Gynecol Pathol 22:362PubMedCrossRefGoogle Scholar
  15. 15.
    Bagg HJ (1936) Experimental production of teratoma testis in a fowl. Am J Cancer 26:69Google Scholar
  16. 16.
    Baker PM, Oliva E, Young RH et al (2001) Ovarian mucinous carcinoids including some with carcinomatous component: a report of 17 cases. Am J Surg Pathol 25:557PubMedCrossRefGoogle Scholar
  17. 17.
    Baker PM, Rosai J, Young RH (2002) Ovarian teratomas with florid benign vascular proliferation: a distinctive finding associated with the neural component of teratomas that may be confused with a vascular neoplasm. Int J Gynecol Pathol 21:16PubMedCrossRefGoogle Scholar
  18. 18.
    Bartlett DJ, Grant JK, Pugh MA, Aherne W (1968) A familial feminizing syndrome. A family showing intersex characteristics with XY chromosomes in three female members. J Obstet Gynaecol Br Commonw 75:199PubMedCrossRefGoogle Scholar
  19. 19.
    Beck JS, Fulmer HF, Lee ST (1969) Solid malignant ovarian teratoma with “embryoid bodies” and trophoblastic differentiation. J Pathol 99:67PubMedCrossRefGoogle Scholar
  20. 20.
    Bergher de Bacalao E, Dominguez I (1969) Unilateral gonadoblastoma in a pregnant woman. Am J Obstet Gynecol 105:1279Google Scholar
  21. 21.
    Bergstrand CG, Czar B (1956) Demonstration of a new protein fraction in serum from human fetus. Scand J Lab Invest 8:174CrossRefGoogle Scholar
  22. 22.
    Bernstein D, Naor S, Rikover M, Manahem H (1974) Hemolytic anemia related to ovarian tumor. Obstet Gynecol 43:276PubMedGoogle Scholar
  23. 23.
    Bhatena D, Haning RV Jr, Shapiro S, Hafez GR (1985) Coexistence of a gonadoblastoma and mixed germ cell–sex cord stroma tumor. Pathol Res Pract 180:203CrossRefGoogle Scholar
  24. 24.
    Bjorkholm E, Lundell M, Gyftodimos A, Silversward C (1990) Dysgerminoma. The Radiumhemmet series 1927–1984. Cancer (Phila) 65:38CrossRefGoogle Scholar
  25. 25.
    Blackwell WJ, Dockerty MB, Masson JC, Mussey RD (1946) Dermoid cysts of the ovary: clinical and pathological significance. Am J Obstet Gynecol 51:151PubMedGoogle Scholar
  26. 26.
    Boczkowski K, Teter J, Sternadel Z (1972) Sibship occurrence of XY gonadal dysgenesis with dysgerminoma. Am J Obstet Gynecol 113:952PubMedGoogle Scholar
  27. 27.
    Bonazzi C, Peccatori F, Colombo N, Lucchini V, Cantu MG, Mangioni C (1994) Pure ovarian immature teratoma, a unique and curable disease: 10 years experience of 32 prospectively treated patients. Obstet Gynecol 84:598PubMedGoogle Scholar
  28. 28.
    Boutross-Tadross O, Saleh R, Asa SL (2007) Follicular variant papillary thyroid carcinoma arising in struma ovarii. Endocr Pathol 18:182PubMedCrossRefGoogle Scholar
  29. 29.
    Brand A, Alves MC, Saraiva C et al (2004) Fetus in fetu – diagnostic criteria and differential diagnosis – a case report and literature review. J Pediatr Surg 39:616PubMedCrossRefGoogle Scholar
  30. 30.
    Brant WO, Rajinvale A, Lovell MA et al (2006) Gonadoblastoma and Turner syndrome. J Urol 175:1858PubMedCrossRefGoogle Scholar
  31. 31.
    Breen JL, Neubecker RD (1967) Ovarian malignancy in children with special reference to the germ cell tumors. Ann NY Acad Sci 142:658PubMedCrossRefGoogle Scholar
  32. 32.
    Cao D, Guo S, Allan RW et al (2009) SALL4 is a novel sensitive and specific marker of ovarian primitive germ cell tumors and is particularly useful in distinguishing yolk sac tumor from clear cell. Am J Surg Pathol 33:894PubMedCrossRefGoogle Scholar
  33. 33.
    Carleton RL, Friedman NB, Bomze EJ (1953) Experimental teratomas of testis. Cancer (Phila) 6:464CrossRefGoogle Scholar
  34. 34.
    Caruso PA, Marsh MR, Minkowitz S, Karten G (1971) An intense clinicopathologic study of 305 teratomas of the ovary. Cancer (Phila) 27:343CrossRefGoogle Scholar
  35. 35.
    Chang MC, Vargas SO, Hornick JL et al (2009) Embryonic stem cell transcription factors and D2-40 (podoplanin) as diagnostic immunohistochemical markers in ovarian germ cell tumors. Int J Gynecol Pathol 28:347PubMedCrossRefGoogle Scholar
  36. 36.
    Cheng L, Thomas A, Roth LM et al (2004) OCT4: a novel biomarker for dysgerminoma of the ovary. Am J Surg Pathol 28:1341PubMedCrossRefGoogle Scholar
  37. 37.
    Cholafranceschi M, Massi D (1995) Gonadoblastoma with coexistent features of mixed germ cell-sex cord-stromal tumor: a case report. Tumori 81:215Google Scholar
  38. 38.
    Chumas JC, Scully RE (1991) Sebaceous tumors arising in ovarian dermoid cysts. Int J Gynecol Pathol 10:356PubMedCrossRefGoogle Scholar
  39. 39.
    Clement PB, Young RH, Scully RE (1987) Endometrioid-like variant of ovarian yolk sac tumor. A clinicopathological analysis of eight cases. Am J Surg Pathol 11:767PubMedCrossRefGoogle Scholar
  40. 40.
    Cohen MB, Friend DS, Molnar JJ, Talerman A (1987) Gonadal endodermal sinus (yolk sac) tumor with pure intestinal differentiation; a new histologic type. Pathol Res Pract 182:609PubMedCrossRefGoogle Scholar
  41. 41.
    Condous G, Thomas J, Okaro E (2003) Placental site trophoblastic tumor masquerading as an ovarian ectopic pregnancy. Ultrasound Obstet Gynecol 21:504PubMedCrossRefGoogle Scholar
  42. 42.
    Cossu-Rocca P, Jones TD, Roth LM et al (2006) Cytokeratin and CD30 expression in dysgerminoma. Hum Pathol 37:1015PubMedCrossRefGoogle Scholar
  43. 43.
    Cossu-Rocca P, Zhang S, Roth LM et al (2006) Chromosome 12p abnormalities in dysgerminoma of the ovary: a FISH analysis. Mod Pathol 19:611PubMedCrossRefGoogle Scholar
  44. 44.
    Dandia SD (1967) Rectovesical fistula following an ovarian dermoid with recurrent vesical calculus. A case report. J Urol 97:85PubMedGoogle Scholar
  45. 45.
    Davis KP, Hartmann LK, Keeney GL, Shapiro H (1996) Primary ovarian carcinoid tumors. Gynecol Oncol 61:259PubMedCrossRefGoogle Scholar
  46. 46.
    Dawson MA, Wilimer T, Yarbro JW (1971) Hemolytic anemia associated with an ovarian tumor. Am J Med 50:552PubMedCrossRefGoogle Scholar
  47. 47.
    Dayal Y, Tashjian AH Jr, Wolfe HJ (1979) Immunocytochemical localization of calcitonin-producing cells in a strumal carcinoid with amyloid stroma. Cancer (Phila) 43:1331CrossRefGoogle Scholar
  48. 48.
    Devaney K, Snyder R, Norris HJ et al (1993) Proliferative and histologically malignant struma ovarii: a clinicopathologic study of 54 cases. Int J Gynecol Pathol 12:333PubMedCrossRefGoogle Scholar
  49. 49.
    Dietl J, Horny HP, Ruck P, Kaiserling E (1993) Dysgerminoma of the ovary. An immunohistochemical study of tumor-infiltrating lymphoreticular cells and tumor cells. Cancer (Phila) 71:2562CrossRefGoogle Scholar
  50. 50.
    Dixon FJ, Moore RA (1952) Tumors of the male sex organs. Atlas of tumor pathology, sect VIII, fasc 31b, 32. Armed Forces Institute of Pathology, Washington, DCGoogle Scholar
  51. 51.
    Djordjevic B, Euscher ED, Malpica A (2007) Growing teratoma syndrome of the ovary: review of literature and first report of a carcinoid tumor arising in a growing teratoma of the ovary. Am J Surg Pathol 31:1913PubMedCrossRefGoogle Scholar
  52. 52.
    Erez SE, Richart RM, Shettles LB (1965) Hashimoto’s disease in a benign cystic teratoma of the ovary. Am J Obstet Gynecol 92:273PubMedGoogle Scholar
  53. 53.
    Erhan Y, Toprak AS, Ozdemir N, Tiras B (1992) Gonadoblastoma and fertility. J Clin Pathol 45:828PubMedCrossRefGoogle Scholar
  54. 54.
    Esheba GE, Pate LL, Longacre TA (2008) Oncofetal protein glypican-3 distinguishes yolk sac tumor from clear cell carcinoma of the ovary. Am J Surg Pathol 32:600PubMedCrossRefGoogle Scholar
  55. 55.
    Evans RW (1957) Developmental stages of embryo-like bodies in teratoma testis. J Clin Pathol 10:321CrossRefGoogle Scholar
  56. 56.
    Evans KN, Taylor H, Zehnder D et al (2004) Increased expression of 25-hydroxyvitamin D-1alpha-hydroxylase in dysgerminoma: a novel form of hypercalcemia of malignancy. Am J Pathol 165:807PubMedCrossRefGoogle Scholar
  57. 57.
    Frazier SD, Bashore RA, Mosier HD (1964) Gonadoblastoma associated with pure gonadal dysgenesis in monozygous twins. J Pediatr 64:740CrossRefGoogle Scholar
  58. 58.
    Friedman NB (1951) The comparative morphogenesis of extragenital and gonadal teratoid tumors. Cancer (Phila) 4:265CrossRefGoogle Scholar
  59. 59.
    Friedman NB, Moore RA (1946) Tumors of the testis. A report of 922 cases. Mil Surg 99:573PubMedGoogle Scholar
  60. 60.
    Fujii S, Konishi I, Suzuki A, Okamura H, Okazaki T, Mori T (1985) Analysis of serum lactic dehydrogenase levels and its isoenzymes in ovarian dysgerminoma. Gynecol Oncol 22:65PubMedCrossRefGoogle Scholar
  61. 61.
    Galager HS, Lewis RP (1973) Sequential gonadoblastoma and choriocarcinoma. Obstet Gynecol 41:123Google Scholar
  62. 62.
    Garg K, Soslow RA, Rivera M et al (2009) Histologically bland “extremely well differentiated” thyroid carcinomas arising in struma ovarii recur and metastasize. Int J Gynecol Pathol 28:222PubMedCrossRefGoogle Scholar
  63. 63.
    Garvin AJ, Pratt-Thomas HR, Spector M, Spicer SS, Williamson HO (1976) Gonadoblastoma: histologic ultrastructural and histochemical observations in five cases. Am J Obstet Gynecol 125:459PubMedGoogle Scholar
  64. 64.
    Gershenson DM (1993) Update on malignant ovarian germ cell tumors. Cancer (Phila) 71:1581CrossRefGoogle Scholar
  65. 65.
    Gershenson DM, Del Junco G, Herson J, Rutledge FN (1983) Endodermal sinus tumor of the ovary. The M.D. Anderson experience. Obstet Gynecol 61:194PubMedGoogle Scholar
  66. 66.
    Gillman J (1948) The development of the gonads in man with consideration of the role of fetal endocrines and the histogenesis of ovarian tumors. Contrib Embryol 32:83Google Scholar
  67. 67.
    Gitlin D, Pericelli A, Gitlin G (1972) Synthesis of alpha-fetoprotein by liver, yolk sac and gastrointestinal tract of the human conceptus. Cancer Res 32:979PubMedGoogle Scholar
  68. 68.
    Gonzalez-Crussi F, Roth LM (1976) The human yolk sac and yolk sac carcinoma. Hum Pathol 7:675PubMedCrossRefGoogle Scholar
  69. 69.
    Gordon A, Lipton D, Woodruff JD (1981) Dysgerminoma: a review of 158 cases from the Emil Novak Ovarian Tumor Registry. Obstet Gynecol 58:497PubMedGoogle Scholar
  70. 70.
    Gupta D, Deavers MT, Silva EG et al (2004) Malignant melanoma involving the ovary: a clinicopathologic and immunohistochemical study of 23 cases. Am J Surg Pathol 28:771PubMedCrossRefGoogle Scholar
  71. 71.
    Halabi M, Oliva E, Mazal PR et al (2002) Prostatic tissue in mature cystic teratomas of the ovary: a report of four cases, including one with features of prostatic adenocarcinoma, and cytogenetic studies. Int J Gynecol Pathol 21:261PubMedCrossRefGoogle Scholar
  72. 72.
    Hart WR, Burkons DM (1979) Germ cell neoplasms arising in gonadoblastomas. Cancer (Phila) 34:669CrossRefGoogle Scholar
  73. 73.
    Hart WR, Regezi JA (1978) Strumal carcinoid of the ovary. Ultrastructural observations and long-term follow-up study. Am J Clin Pathol 69:356PubMedGoogle Scholar
  74. 74.
    Heifetz SA, Cushing B, Giller R et al (1998) Immature teratomas in children: Pathologic considerations. A report from the combined Pediatric Oncology Group/Children’s Cancer Group. Am J Surg Pathol 22:1115PubMedCrossRefGoogle Scholar
  75. 75.
    Hingorani V, Narula RK, Bhalla S (1963) Salmonella typhi infection in an ovarian dermoid. Report of a case. Obstet Gynecol 22:118PubMedGoogle Scholar
  76. 76.
    Hirakawa T, Tsuneyoshi M, Enjoji M (1989) Squamous cell carcinoma arising in mature cystic teratoma of the ovary. Clinicopathologic and topographic analysis. Am J Surg Pathol 13:397PubMedCrossRefGoogle Scholar
  77. 77.
    Hoei-Hansen CE, Kraggerud SM, Abeler VM et al (2007) Ovarian dysgerminomas are characterised by frequent KIT mutations and abundant expression of pluripotency markers. Mol Cancer 6:12PubMedCrossRefGoogle Scholar
  78. 78.
    Hristov AC, Young RH, Vang R et al (2007) Ovarian metastases of appendiceal tumors with goblet cell carcinoidlike and signet ring cell patterns: a report of 30 cases. Am J Surg Pathol 31:1502PubMedCrossRefGoogle Scholar
  79. 79.
    Hughesdon PE, Kumarasamy T (1970) Mixed germ cell tumors (gonadoblastomas) in normal and dysgenetic gonads. Virch Arch (Pathol Anat) 349:258CrossRefGoogle Scholar
  80. 80.
    Ishida T, Tagatz GE, Okagaki T (1976) Gonadoblastoma. Ultrastructural evidence of testicular origin. Cancer (Phila) 37:1770CrossRefGoogle Scholar
  81. 81.
    Jacobs AJ, Newland JR, Green RK (1982) Pure choriocarcinoma of the ovary. Obstet Gynecol Surv 37:603PubMedCrossRefGoogle Scholar
  82. 82.
    Jacobsen GK, Talerman A (1989) Atlas of germ cell tumors. Munksgaard, CopenhagenGoogle Scholar
  83. 83.
    Judd HL, Scully RE, Atkins L, Neer RM, Kliman B (1970) Pure gonadal dysgenesis with progressive hirsutism. N Engl J Med 282:881PubMedCrossRefGoogle Scholar
  84. 84.
    Kawahara H (1963) Struma ovarii with ascites and hydrothorax. Am J Obstet Gynecol 85:85PubMedGoogle Scholar
  85. 85.
    Kazancigil TR, Laquer W, Ladewig P (1940) Papilloendothelioma of the ovary; report of three cases and discussion of Schiller’s “mesonephroma ovarii”. Am J Cancer 40:199Google Scholar
  86. 86.
    Kemp B, Hauptmann S, Schroder W, Amo-Takyi B, Leeners B, Rath W (1995) Dysgerminoma of the ovary in a patient with triple-X syndrome. Int J Obstet Gynecol 50:51CrossRefGoogle Scholar
  87. 87.
    Kerseladze AI, Kulinich SI (1994) Peritoneal strumosis. Pathol Res Pract 190:1082CrossRefGoogle Scholar
  88. 88.
    King ME, Mouradian JA, Micha JP, Chaganti RSK, Allen SL (1985) Immature teratoma of the ovary with predominant malignant retinal anlage tumor. A parthenogenetically derived tumor. Am J Surg Pathol 9:221PubMedCrossRefGoogle Scholar
  89. 89.
    King ME, Hubbell MJ, Talerman A (1991) Mixed germ cell tumor of the ovary with prominent polyembryoma component. Int J Gynecol Pathol 10:88PubMedCrossRefGoogle Scholar
  90. 90.
    Klein HZ (1974) Mucinous carcinoid tumor of the vermiform appendix. Cancer (Phila) 33:770CrossRefGoogle Scholar
  91. 91.
    Kleinman GM, Young RH, Scully RE (1993) Primary neuroectodermal tumors of the ovary. A report of 25 cases. Am J Surg Pathol 17:764PubMedCrossRefGoogle Scholar
  92. 92.
    Kommoss F, Franklin WA, Talerman A (1989) Estrogen and progesterone receptors in endodermal sinus (yolk sac) tumor. Evaluation of immunocytochemical and biochemical methods. J Reprod Med 34:943PubMedGoogle Scholar
  93. 93.
    Kommoss F, Bibbo M, Talerman A (1990) Nuclear deoxyribonucleic acid content (ploidy) of endodermal sinus (yolk sac) tumor. Lab Invest 62:223PubMedGoogle Scholar
  94. 94.
    Kraggerud SM, Szymanska J, Abeler VM et al (2000) DNA copy number changes in malignant ovarian germ cell tumors. Cancer Res 60:3025PubMedGoogle Scholar
  95. 95.
    Krumerman MS, Chung A (1977) Squamous carcinoma arising in benign cystic teratoma of the ovary. Cancer (Phila) 39:1237CrossRefGoogle Scholar
  96. 96.
    Kurman RJ, Norris HJ (1976) Endodermal sinus tumor of the ovary. A clinical and pathological analysis of 71 cases. Cancer (Phila) 38:2404CrossRefGoogle Scholar
  97. 97.
    Kurman RJ, Norris HJ (1976) Embryonal carcinoma of the ovary. A clinicopathologic entity distinct from endodermal sinus tumor resembling embryonal carcinoma of the adult testis. Cancer (Phila) 38:2420CrossRefGoogle Scholar
  98. 98.
    Kurman RJ, Norris HJ (1976) Malignant mixed germ cell tumors of the ovary. A clinical and pathological analysis of 30 cases. Obstet Gynecol 48:579PubMedGoogle Scholar
  99. 99.
    Lacson AG, Gillis DA, Shawwa A (1988) Malignant mixed germ cell–sex cord stromal tumors of the ovary associated with isosexual precocious puberty. Cancer (Phila) 61:2122CrossRefGoogle Scholar
  100. 100.
    Lau YF, Li Y, Kido T (2009) Gonadoblastoma locus and the TSPY gene on the human Y chromosome. Birth Defects Res C Embryo Today 87:114PubMedCrossRefGoogle Scholar
  101. 101.
    Letterie GS, Page DC (1995) Dysgerminoma and gonadal dysgenesis in 46,XX female with no evidence of Y chromosomal DNA. Gynecol Oncol 57:423PubMedCrossRefGoogle Scholar
  102. 102.
    Linder D, Power J (1970) Further evidence for postmeiotic origin of teratomas in the human female. Ann Hum Genet 34:21PubMedCrossRefGoogle Scholar
  103. 103.
    Linder D, McCaw BK, Hecht F (1975) Parthenogenic origin of benign ovarian teratoma. N Engl J Med 292:63PubMedCrossRefGoogle Scholar
  104. 104.
    Lu KH, Gershenson MD (2005) Update on the management of ovarian germ cell tumors. J Reprod Med 50:417PubMedGoogle Scholar
  105. 105.
    Lynn JA, Varon HH, Kingsley WB, Martin JH (1967) Ultrastructure and biochemical studies of estrogen-secreting capacity of a “non-functional” ovarian neoplasm (dysgerminoma). Am J Pathol 51:639PubMedGoogle Scholar
  106. 106.
    Mackay AM, Pattigrew N, Symington T, Neville AM (1974) Tumors of dysgenetic gonads (gonadoblastoma). Ultrastructural and steroidogenic aspects. Cancer (Phila) 34:1108CrossRefGoogle Scholar
  107. 107.
    Maeda D, Ota S, Takazawa Y et al (2009) Glypican-3 expression in clear cell adenocarcinoma of the ovary. Mod Pathol 22:824PubMedGoogle Scholar
  108. 108.
    Magi-Galluzi C, O’Connell JT, Neffen E et al (2001) Are mucinous cystadenomas of the ovary derived from germ cells? A genetic analysis (Abstract). Mod Pathol 14:140A (abstract # 818)Google Scholar
  109. 109.
    Malkasian GD Jr, Symmonds RE, Dockerty MB (1965) Malignant ovarian teratomas. Report of 31 cases. Obstet Gynecol 25:810PubMedGoogle Scholar
  110. 110.
    Malkasian GD Jr, Dockerty MB, Symmonds RE (1967) Benign cystic teratomas. Obstet Gynecol 29:719PubMedGoogle Scholar
  111. 111.
    Marin-Padilla M (1965) Origin, nature and significance of the “embryoids” of human teratomas. Virchows Arch (Pathol Anat) 340:105CrossRefGoogle Scholar
  112. 112.
    Marrubini G (1949) Primary chorionepithelioma of the ovary. Report of two cases. Acta Obstet Gynecol Scand 28:251PubMedCrossRefGoogle Scholar
  113. 113.
    Mazur MT, Talbot WH Jr, Talerman A (1988) Endodermal sinus tumor and mucinous cystadenofibroma of the ovary. Occurrence in an 82-year-old woman. Cancer (Phila) 62:2011CrossRefGoogle Scholar
  114. 114.
    McCluggage WG, Bissonnette JP, Young RH (2006) Primary malignant melanoma of the ovary: a report of 9 definite or probable cases with emphasis on their morphologic diversity and mimicry of other primary and secondary ovarian neoplasms. Int J Gynecol Pathol 25:321PubMedCrossRefGoogle Scholar
  115. 115.
    McDonough PG, Byrd JR, Tho PT, Otken L (1976) Gonadoblastoma in a true hermaphrodite with 46XX karyotype. Obstet Gynecol 47:355PubMedGoogle Scholar
  116. 116.
    McKay DG, Hertig AT, Adams EC, Danziger S (1953) Histochemical observations on the germ cells of human embryos. Anat Rec 117:201PubMedCrossRefGoogle Scholar
  117. 117.
    McKenney JK, Soslow RA, Longacre TA (2008) Ovarian mature teratomas with mucinous epithelial neoplasms: morphologic heterogeneity and association with pseudomyxoma peritonei. Am J Surg Pathol 32:645PubMedCrossRefGoogle Scholar
  118. 118.
    Michal M, Vanecek T, Sima R et al (2006) Mixed germ cell sex cord-stromal tumors of the testis and ovary. Morphological, immunohistochemical and molecular genetic study of seven cases. Virchows Archs 448:612CrossRefGoogle Scholar
  119. 119.
    Miettinen M, Talerman A, Wahlstrom T, Astengo-Osuna C, Virtanen I (1985) Cellular differentiation in ovarian sex cord-stromal and germ-cell tumors studied with antibodies to intermediate-filament proteins. Am J Surg Pathol 9:640PubMedCrossRefGoogle Scholar
  120. 120.
    Miettinen M, Virtanen I, Talerman A (1985) Intermediate filament proteins in human testis and testicular germ-cell tumors. Am J Pathol 120:402PubMedGoogle Scholar
  121. 121.
    Mueller CW, Topkins P, Lapp WA (1950) Dysgerminoma of the ovary. An analysis of 427 cases. Am J Obstet Gynecol 60:153PubMedGoogle Scholar
  122. 122.
    Nakashima M, Nagasaka T, Fukata S, Oiwa N, Nara Y, Fukatsu T, Takeuchi J (1989) Ovarian gonadoblastoma with dysgerminoma in a woman with two normal children. Hum Pathol 20:814PubMedCrossRefGoogle Scholar
  123. 123.
    Nielsen SNJ, Scheithauer BW, Gaffey TA (1985) Gliomatosis peritonei. Cancer (Phila) 56:2499CrossRefGoogle Scholar
  124. 124.
    Nogales FF Jr, Silverberg SG, Bloustein PA, Martinez-Hernandez A, Pierce GB (1977) Yolk sac carcinoma (endodermal sinus tumor). Ultrastructure and histogenesis of gonadal and extragonadal tumors in comparison with normal human yolk sac. Cancer (Phila) 39:1462CrossRefGoogle Scholar
  125. 125.
    Nogales FF, Bergeron C, Carvia RE, Alvaro T, Fulwood HR (1996) Ovarian endometrioid tumors with yolk sac tumor component, an unusual form of ovarian neoplasm. Analysis of six cases. Am J Surg Pathol 20:1056PubMedCrossRefGoogle Scholar
  126. 126.
    Nomura K, Ohama K, Okamoto E, Fujiwara A (1983) Cytogenetic studies of multiple ovarian dermoid cysts in a single host. Acta Obstet Gynecol Jpn 35:1938Google Scholar
  127. 127.
    Nomura K, Matsui T, Aizawa S (1999) Gonadoblastoma with proliferation resembling Sertoli cell tumor. Int J Gynecol Pathol 18:91PubMedCrossRefGoogle Scholar
  128. 128.
    Norgaard-Pedersen B, Albrechtsen R, Teilum G (1975) Serum alpha-fetoprotein as a marker for endodermal sinus tumor (yolk sac tumor), or a vitelline component of teratocarcinoma. Acta Pathol Microbiol Scand A 83:573PubMedGoogle Scholar
  129. 129.
    Norris HJ, Jensen RD (1972) Relative frequency of ovarian neoplasms in children and adolescents. Cancer (Phila) 30:713CrossRefGoogle Scholar
  130. 130.
    Norris HJ, Zirkin HJ, Benson WL (1976) Immature (malignant) teratoma of the ovary. A clinical and pathologic study of 58 cases. Cancer (Phila) 37:2359CrossRefGoogle Scholar
  131. 131.
    O’Connor DM, Norris HJ (1994) The influence of grade on the outcome of stage I ovarian immature (malignant) teratomas and the reproducibility of grading. Int J Gynecol Pathol 13:283PubMedCrossRefGoogle Scholar
  132. 132.
    Obata NH, Nakashima N, Kawai M, Kikkawa F, Mamba S, Tomoda Y (1995) Gonadoblastoma with dysgerminoma in one ovary and gonadoblastoma with dysgerminoma and yolk sac tumor in the contralateral ovary in a girl with 46,XX karyotype. Gynecol Oncol 58:124PubMedCrossRefGoogle Scholar
  133. 133.
    Pantoja E, Noy MA, Axtmayer RW, Colon FE, Pelegrina I (1975) Ovarian dermoids and their complications. Comprehensive historical review. Obstet Gynecol Surv 30:1PubMedCrossRefGoogle Scholar
  134. 134.
    Pantoja E, Rodriguez-Ibanez I, Axtmayer RW, Noy MA, Pelegrina I (1975) Complications of dermoid tumors of the ovary. Obstet Gynecol 45:89PubMedGoogle Scholar
  135. 135.
    Park IJ, Pyeatte JC, Jones HW, Woodruff JD (1972) Gonadoblastoma in a true hermaphrodite with 46XY genotype. Obstet Gynecol 40:466PubMedGoogle Scholar
  136. 136.
    Park JY, Kim DY, Kim JH et al (2008) Malignant transformation of mature cystic teratoma of the ovary: experience at a single institution. Eur J Obstet Gynecol Reprod Biol 141:173PubMedCrossRefGoogle Scholar
  137. 137.
    Parkash V, Carcangiu ML (1995) Transformation of ovarian dysgerminoma to yolk sac tumor: evidence for a histogenetic continuum. Mod Pathol 8:881PubMedGoogle Scholar
  138. 138.
    Parrington JM, West LF, Povey S (1984) The origin of ovarian teratomas. J Med Genet 21:4PubMedCrossRefGoogle Scholar
  139. 139.
    Payne D, Muss HB, Homesley HD, Jobson VM, Baird FG (1981) Autoimmune hemolytic anemia and ovarian dermoid cysts. Case report and review of the literature. Cancer (Phila) 48:721CrossRefGoogle Scholar
  140. 140.
    Peccatori F, Bonazzi C, Chiari F, Landoni F, Colombo N, Mangioni C (1995) Surgical management of malignant ovarian germ cell tumors: 10 years’ experience with 129 patients. Obstet Gynecol 86:367PubMedCrossRefGoogle Scholar
  141. 141.
    Pedowitz P, Felmus LB, Grayzel DM (1955) Dysgerminoma of the ovary. Prognosis and treatment. Am J Obstet Gynecol 70:1284PubMedGoogle Scholar
  142. 142.
    Peterson WF (1956) Solid histologically benign teratomas of the ovary. A report of four cases and review of the literature. Am J Obstet Gynecol 72:1094PubMedGoogle Scholar
  143. 143.
    Peterson WF (1957) Malignant degeneration of benign cystic teratomas of the ovary: a collective review of the literature. Obstet Gynecol Surv 12:793PubMedCrossRefGoogle Scholar
  144. 144.
    Peterson WF, Prevost EC, Edmunds FT, Huntley JM Jr, Morris FK (1955) Benign cystic teratomas of the ovary. A clinicostatistical study of 1007 cases with review of the literature. Am J Obstet Gynecol 70:368PubMedGoogle Scholar
  145. 145.
    Peyron A (1939) Faits nouveaux relatifs l’origine et l’histogenese des embryomes. Bull Assoc Fr Cancer 28:658Google Scholar
  146. 146.
    Pierce GB Jr, Dixon FJ (1959) Testicular teratomas. 1. Demonstration of teratogenesis by metamorphosis of multipotential cells. Cancer (Phila) 12:573CrossRefGoogle Scholar
  147. 147.
    Pierce GB Jr, Dixon FJ (1959) Testicular teratomas. 2. Teratocarcinoma as ascitic tumor. Cancer (Phila) 12:584CrossRefGoogle Scholar
  148. 148.
    Pierce GB Jr, Midgley AR (1963) The origin and function of human syncytiotrophoblastic giant cells. Am J Pathol 43:153PubMedGoogle Scholar
  149. 149.
    Pierce GB Jr, Verney EL (1961) An in vitro and in vivo study of differentiation in teratocarcinomas. Cancer (Phila) 14:1017CrossRefGoogle Scholar
  150. 150.
    Pierce GB Jr, Midgley AR, Beals TF (1962) An ultrastructural study of differentiation and maturation of trophoblast of the monkey. Lab Invest 13:451Google Scholar
  151. 151.
    Pierce GB Jr, Midgley AR, Sri Ram J, Feldman JD (1964) Parietal yolk sac carcinoma. Clue to the histogenesis of Reichert’s membrane of the mouse embryo. Am J Pathol 41:549Google Scholar
  152. 152.
    Pitman MB, Triratanachat S, Young RH et al (2004) Hepatocyte paraffin 1 antibody does not distinguish primary ovarian tumors with hepatoid differentiation from metastatic hepatocellular carcinoma. Int J Gynecol Pathol 23:58PubMedGoogle Scholar
  153. 153.
    Poulos C, Cheng L, Zhang S et al (2006) Analysis of ovarian teratomas for isochromosome 12p: evidence supporting a dual histogenetic pathway for teratomatous elements. Mod Pathol 19:766PubMedGoogle Scholar
  154. 154.
    Prat J, Bhan AK, Dickersin GR, Robboy SJ, Scully RE (1982) Hepatoid yolk sac tumor of the ovary (endodermal sinus tumor with hepatoid differentiation). A light microscopic ultrastructural and immunohistochemical study of seven cases. Cancer (Phila) 50:2355CrossRefGoogle Scholar
  155. 155.
    Pratt-Thomas HR, Cooper JM (1976) Gonadoblastoma with tubal pregnancy. Am J Clin Pathol 65:121PubMedGoogle Scholar
  156. 156.
    Rabban JT, Lerwill MF, McCluggage WG et al (2009) Primary ovarian carcinoid tumors may express CDX-2: a potential pitfall in distinction from metastatic intestinal carcinoid tumors involving the ovary. Int J Gynecol Pathol 28:41PubMedCrossRefGoogle Scholar
  157. 157.
    Ramalingam P, Malpica A, Silva EG et al (2004) The use of cytokeratin 7 and EMA in differentiating ovarian yolk sac tumors from endometrioid and clear cell carcinomas. Am J Surg Pathol 28:1499PubMedCrossRefGoogle Scholar
  158. 158.
    Rashad MH, Fathalla MF, Kerr MC (1966) Sex chromatin and chromosome analysis in ovarian teratomas. Am J Obstet Gynecol 96:461PubMedGoogle Scholar
  159. 159.
    Riopel MA, Spellerberg A, Griffin CA et al (1998) Genetic analysis of ovarian germ cell tumors by comparative genomic hybridization. Cancer Res 58:3105PubMedGoogle Scholar
  160. 160.
    Robboy SJ, Scully RE (1970) Ovarian teratoma with glial implants on the peritoneum. An analysis of 12 cases. Hum Pathol 1:643PubMedCrossRefGoogle Scholar
  161. 161.
    Robboy SJ, Scully RE (1980) Strumal carcinoid of the ovary. An analysis of 50 cases of a distinctive tumor composed of thyroid tissue and carcinoid. Cancer (Phila) 46:2019CrossRefGoogle Scholar
  162. 162.
    Robboy SJ, Scully RE, Norris HJ (1974) Carcinoid metastatic to the ovary. A clinicopathologic analysis of 35 cases. Cancer (Phila) 33:798CrossRefGoogle Scholar
  163. 163.
    Robboy SJ, Norris HJ, Scully RE (1975) Insular carcinoid primary in the ovary: a clinicopathologic analysis of 48 cases. Cancer (Phila) 36:404CrossRefGoogle Scholar
  164. 164.
    Robboy SJ, Scully RE, Norris HJ (1977) Primary trabecular carcinoid of the ovary. Obstet Gynecol 49:202PubMedGoogle Scholar
  165. 165.
    Robboy SJ, Shaco-Levy R, Peng RY et al (2009) Malignant struma ovarii: an analysis of 88 cases, including 27 with extraovarian spread. Int J Gynecol Pathol 28:405PubMedCrossRefGoogle Scholar
  166. 166.
    Rose LI, Underwood RH, Williams GH, Pincus GS (1974) Pure gonadal dysgenesis. Studies of in vitro androgen metabolism. Am J Med 57:957PubMedCrossRefGoogle Scholar
  167. 167.
    Roth LM, Kerseladze AI (2008) Highly differentiated follicular carcinoma arising from struma ovarii: a report of three cases, a review of the literature and reasessement of the so-called peritoneal strumosis. Int J Gynecol Pathol 27:213PubMedCrossRefGoogle Scholar
  168. 168.
    Roth LM, Talerman A (2006) Recent advances in the pathology and classification of ovarian germ cell tumors. Int J Gynecol Pathol 25:305PubMedCrossRefGoogle Scholar
  169. 169.
    Roth LM, Talerman A (2007) The enigma of struma ovarii. Pathology 39:139PubMedCrossRefGoogle Scholar
  170. 170.
    Roth LM, Miller AWIII, Talerman A (2007) Typical thyroid-type carcinoma arising in struma ovarii: a report of 4 cases and review of the literature. Int J Gynecol Pathol 27:496CrossRefGoogle Scholar
  171. 171.
    Rutgers JL, Scully RE (1986) Functioning ovarian tumors with peripheral steroid cell proliferation. A report of 24 cases. Int J Gynecol Pathol 5:319PubMedCrossRefGoogle Scholar
  172. 172.
    Rutgers JL, Young RH, Scully RE (1987) Ovarian yolk sac tumor arising from endometrioid carcinoma. Hum Pathol 18:1296PubMedCrossRefGoogle Scholar
  173. 173.
    Santesson L (1947) Clinical and pathological survey of ovarian tumours treated at the Radiumhemmet. 1. Dysgerminoma. Acta Radiol (Stockh) 28:643CrossRefGoogle Scholar
  174. 174.
    Schellhas HF (1974) Malignant potential of the dysgenetic gonad. Part 1. Obstet Gynecol 44:298PubMedGoogle Scholar
  175. 175.
    Schellhas HF (1974) Malignant potential of the dysgenetic gonad. Part 2. Obstet Gynecol 44:455PubMedGoogle Scholar
  176. 176.
    Schellhas HF, Trujillo JM, Rutledge FN, Cork A (1971) Germ cell tumors associated with XY gonadal dysgenesis. Am J Obstet Gynecol 109:1197PubMedGoogle Scholar
  177. 177.
    Schiller W (1939) Mesonephroma ovarii. Am J Cancer 35:1Google Scholar
  178. 178.
    Schmidt J, Derr V, Heinrich MC et al (2007) BRAF in papillary thyroid carcinoma of ovary (struma ovarii). Am J Surg Pathol 31:1337PubMedCrossRefGoogle Scholar
  179. 179.
    Schmitz EF (1925) Malignant endothelioma of perithelioma type in the ovary. Am J Obstet Gynecol 9:247Google Scholar
  180. 180.
    Schwartz PE, Morris JM (1988) Serum lactic dehydrogenase. A tumor marker for dysgerminoma. Obstet Gynecol 72:511PubMedGoogle Scholar
  181. 181.
    Scully RE (1953) Gonadoblastoma. A gonadal tumor related to dysgerminoma (seminoma) and capable of sex hormone production. Cancer (Phila) 6:455CrossRefGoogle Scholar
  182. 182.
    Scully RE (1970) Gonadoblastoma. Cancer (Phila) 25:1340CrossRefGoogle Scholar
  183. 183.
    Scully RE (1970) Sex cord tumor with annular tubules. A distinctive ovarian tumor of the Peutz–Jeghers syndrome. Cancer (Phila) 25:1107CrossRefGoogle Scholar
  184. 184.
    Scully RE (1999) Histological typing of ovarian tumours, World Health Organization histological classification of tumours, 2nd edn. Springer, HeidelbergCrossRefGoogle Scholar
  185. 185.
    Scully RE, Young RH, Clement PB (1998) Tumors of the ovary, maldeveloped gonads and broad ligament. Atlas of tumor pathology. Fascicle 23, 3rd series. Armed Forces Institute of Pathology, Washingon, DCGoogle Scholar
  186. 186.
    Serov SF, Scully RE, Sobin LH (1973) Histological typing of ovarian tumors. International histological classification of tumors, no 9. World Health Organization, GenevaGoogle Scholar
  187. 187.
    Serratoni FT, Robboy SJ (1975) Ultrastructure of primary and metastatic ovarian carcinoids: analysis of 11 cases. Cancer (Phila) 36:157CrossRefGoogle Scholar
  188. 188.
    Sever M, Jones TD, Roth LM et al (2005) Expression of CD117 (c-kit) receptor in dysgerminoma of the ovary: diagnostic and therapeutic implications. Mod Pathol 18:1411PubMedCrossRefGoogle Scholar
  189. 189.
    Shah KD, Kaffe S, Gilbert F, Dolgin S, Gertner M (1988) Unilateral microscopic gonadoblastoma in a prepubertal Turner mosaic with Y chromosome material identified by restriction fragment analysis. Am J Clin Pathol 90:622PubMedGoogle Scholar
  190. 190.
    Shigematsu T, Kamura T, Airnia T et al (2000) DNA polymorphism analysis of a pure nongestational choriocarcinoma of the ovary: case report. Eur J Gynecol Oncol 21:153Google Scholar
  191. 191.
    Shirai T, Itoh T, Yoshiki T, Noro T, Tomino Y, Hayasaka T (1976) Immunofluorescent demonstration of alpha-fetoprotein, and other plasma proteins in yolk sac tumor. Cancer (Phila) 38:1661CrossRefGoogle Scholar
  192. 192.
    Simard LC (1957) Polyembryonic embryoma of the ovary of parthenogenetic origin. Cancer (Phila) 10:215CrossRefGoogle Scholar
  193. 193.
    Smith FG (1946) Pathology and physiology of struma ovarii. Arch Surg 53:603PubMedCrossRefGoogle Scholar
  194. 194.
    Snyder RR, Tavassoli FA (1986) Ovarian strumal carcinoid: Immunohistochemical, ultrastructural, and clinicopathologic observations. Int J Gynecol Pathol 5:187PubMedCrossRefGoogle Scholar
  195. 195.
    Soga J, Osaka M, Yakawa Y (2000) Carcinoids of the ovary: an analysis of 329 reported cases. J Exp Clin Cancer Res 19:271PubMedGoogle Scholar
  196. 196.
    Speleman F, Dermaut B, DePotter CR et al (1997) Monosomy 22 in a mixed germ cell-sex cord-stromal tumor of the ovary. Genes Chromosomes Cancer 19:192PubMedCrossRefGoogle Scholar
  197. 197.
    Sporrong B, Falkmer S, Robboy SJ et al (1982) Neurohormonal peptides in ovarian carcinoids. An immunohistochemical study of 81 primary carcinoids and of intraovarian metastases from six midgut carcinoids. Cancer (Phila) 49:68CrossRefGoogle Scholar
  198. 198.
    Stagno PA, Petras RE, Hart WR (1987) Strumal carcinoids of the ovary. An immunohistologic and ultrastructural study. Arch Pathol Lab Med 111:440PubMedGoogle Scholar
  199. 199.
    Stamp GWH, McConnell EM (1983) Malignancy arising in cystic ovarian teratomas. Br J Obstet Gynecol 90:671CrossRefGoogle Scholar
  200. 200.
    Stevens LC (1959) Embryology of testicular teratomas in strain 129 mice. J Natl Cancer Inst 23:1249PubMedGoogle Scholar
  201. 201.
    Stevens LC (1960) Embryonic potency of embryoid bodies derived from a transplantable testicular teratoma of the mouse. Dev Biol 2:285PubMedCrossRefGoogle Scholar
  202. 202.
    Stevens LC (1962) The biology of teratomas including evidence indicating their origin from primordial germ cells. Ann Biol 1:585Google Scholar
  203. 203.
    Subbuswamy SG, Gibbs NM, Ross CF, Morson BC (1974) Goblet cell carcinoid of the appendix. Cancer (Phila) 34:338CrossRefGoogle Scholar
  204. 204.
    Szokol M, Kondrai G, Papp Z (1977) Gonadal malignancy and 46 XY karyotype in a true hermaphrodite. Obstet Gynecol 49:358PubMedGoogle Scholar
  205. 205.
    Szyfelbein WM, Young RH, Scully RE (1994) Cystic struma ovarii: a frequently unrecognized tumor. A report of 20 cases. Am J Surg Pathol 18:785PubMedCrossRefGoogle Scholar
  206. 206.
    Szyfelbein WM, Young RH, Scully RE (1995) Struma ovarii simulating ovarian tumors of other types. A report of 30 cases. Am J Surg Pathol 19:21PubMedCrossRefGoogle Scholar
  207. 207.
    Takeda A, Ishizuka T, Goto T et al (1982) Polyembryoma of ovary producing alpha-fetoprotein and HCG. Immunoperoxidase and electron microscopic study. Cancer (Phila) 49:1878CrossRefGoogle Scholar
  208. 208.
    Talerman A (1971) Gonadoblastoma and dysgerminoma in two siblings with dysgenetic gonads. Obstet Gynecol 38:416PubMedGoogle Scholar
  209. 209.
    Talerman A (1972) A distinctive gonadal neoplasm related to gonadoblastoma. Cancer (Phila) 30:1219CrossRefGoogle Scholar
  210. 210.
    Talerman A (1972) A mixed germ cell-sex cord stroma tumor in a normal female infant. Obstet Gynecol 40:473PubMedGoogle Scholar
  211. 211.
    Talerman A (1974) Gonadoblastoma associated with embryonal carcinoma. Obstet Gynecol 43:138PubMedGoogle Scholar
  212. 212.
    Talerman A (1975) The incidence of yolk sac tumor (endodermal sinus tumor) elements in germ cell tumors of the testis in adults. Cancer (Phila) 36:211CrossRefGoogle Scholar
  213. 213.
    Talerman A (1980) The pathology of gonadal neoplasms composed of germ cells and sex cord stroma derivatives. Pathol Res Pract 170:24PubMedCrossRefGoogle Scholar
  214. 214.
    Talerman A (1984) Carcinoid tumors of the ovary. J Cancer Res Clin Oncol 107:125PubMedCrossRefGoogle Scholar
  215. 215.
    Talerman A (1987) Ovarian Sertoli–Leydig cell tumor (androblastoma) with retiform pattern: A clinicopathologic study. Cancer (Phila) 60:3056CrossRefGoogle Scholar
  216. 216.
    Talerman A, Delemarre JFM (1975) Gonadoblastoma associated with embryonal carcinoma in an anatomically normal male. J Urol 113:355PubMedGoogle Scholar
  217. 217.
    Talerman A, Evans MI (1982) Primary trabecular carcinoid tumor of the ovary. Cancer (Phila) 50:1407CrossRefGoogle Scholar
  218. 218.
    Talerman A, Haije WG (1974) Alpha-fetoprotein and germ cell tumors. A possible role of yolk sac tumor in production of alpha-fetoprotein. Cancer (Phila) 34:1722CrossRefGoogle Scholar
  219. 219.
    Talerman A, Haije WG (1985) Ovarian Sertoli cell tumor with retiform and heterologous elements. Am J Surg Pathol 9:459PubMedCrossRefGoogle Scholar
  220. 220.
    Talerman A, Okagaki T (1985) Ultrastructural features of primary trabecular carcinoid tumor of the ovary. Int J Gynecol Pathol 4:153PubMedCrossRefGoogle Scholar
  221. 221.
    Talerman A, Roth LM (2007) Recent advances in the pathology and classification of gonadal neoplasms composed of germ cells and sex cord derivatives. Int J Gynecol Pathol 26:313PubMedCrossRefGoogle Scholar
  222. 222.
    Talerman A, van der Harten JJ (1977) A mixed germ cell-sex cord stroma tumor of the ovary associated with isosexual precocious puberty in a normal female child. Cancer (Phila) 40:889CrossRefGoogle Scholar
  223. 223.
    Talerman A, Huyzinga WT, Kuipers T (1973) Dysgerminoma. Clinicopathologic study of 22 cases. Obstet Gynecol 41:137PubMedGoogle Scholar
  224. 224.
    Talerman A, Haije WG, Baggerman L (1977) Alpha-1-antitrypsin (AAT) and alpha-foetoprotein (AFP) in sera of patients with germ cell neoplasms. Value as tumor markers in patients with endodermal sinus tumour (yolk sac tumour). Int J Cancer 19:741PubMedCrossRefGoogle Scholar
  225. 225.
    Talerman A, van der Pompe WB, Haije WG, Baggerman L, Boekestein-Tjahjadi HM (1977) Alpha-fetoprotein and carcinoembryonic antigen in germ cell neoplasms. Br J Cancer 35:288PubMedCrossRefGoogle Scholar
  226. 226.
    Talerman A, Haije WG, Baggerman L (1978) Serum alpha-fetoprotein in diagnosis and management of endodermal sinus (yolk sac) tumor and mixed germ cell tumor of the ovary. Cancer (Phila) 41:272CrossRefGoogle Scholar
  227. 227.
    Talerman A, Haije WG, Baggerman L (1980) Serum alpha-fetoprotein (AFP) in patients with germ cell tumors of the gonads and extragonadal sites. Correlation between endodermal sinus (yolk sac) tumor and raised serum AFP. Cancer (Phila) 46:340CrossRefGoogle Scholar
  228. 228.
    Talerman A, Verp M, Senekjian E, Gilewski T, Vogelzang N (1990) True hermaphrodite with normal female 46, XX karyotype, bilateral gonadoblastomas and dysgerminomas and normal pregnancy. Cancer (Phila) 66:2668CrossRefGoogle Scholar
  229. 229.
    Tavassoli FA (1983) A combined germ cell-gonadal stromal-epithelial tumor of the ovary. Am J Surg Pathol 7:73PubMedCrossRefGoogle Scholar
  230. 230.
    Tavassoli FA, Devilee P (2003) Pathology and genetics of tumors of the breast and female genital organs, World Health Organization classification of tumors. IARC, LyonGoogle Scholar
  231. 231.
    Teilum G (1944) Homologous tumours in ovary and testis: contribution to classification of gonadal tumours. Acta Obstet Gynecol Scand 24:480CrossRefGoogle Scholar
  232. 232.
    Teilum G (1946) Gonocytoma; homologous ovarian and testicular tumours. 1. With discussion of “mesonephroma ovarii” (Schiller: Am J Cancer 1939). Acta Pathol Microbiol Scand 23:242Google Scholar
  233. 233.
    Teilum G (1950) “mesonephroma ovarii” (Schiller) extraembryonic mesoblastoma of germ cell origin in ovary and testis. Acta Pathol Microbiol Scand 27:249CrossRefGoogle Scholar
  234. 234.
    Teilum G (1959) Endodermal sinus tumors of the ovary and testis. Comparative morphogenesis of the so-called mesonephroma ovarii (Schiller) and extraembryonic (yolk sac-allantoic) structures of the rat’s placenta. Cancer (Phila) 12:1092CrossRefGoogle Scholar
  235. 235.
    Teilum G (1965) Classification of endodermal sinus tumour (mesoblastoma vitellinum) and so-called embryonal carcinoma of the ovary. Acta Pathol Microbiol Scand 64:407PubMedGoogle Scholar
  236. 236.
    Teter J (1970) Prognosis, malignancy and curability of the germ cell tumor occurring in dysgenetic gonads. Am J Obstet Gynecol 108:894PubMedGoogle Scholar
  237. 237.
    Thomas GM, Dembo AJ, Hacker NE, DePetrillo AD (1987) Current therapy for dysgerminoma of the ovary. Obstet Gynecol 70:268PubMedGoogle Scholar
  238. 238.
    Tiltman AJ (1985) Ependymal cyst of the ovary. South Afr Med J 68:424Google Scholar
  239. 239.
    Tokuoka S, Aoki Y, Yokoyama T, Ishii T (1985) A mixed germ cell-sex cord stromal tumor of the ovary with retiform tubular structure. A case report. Int J Gynecol Pathol 4:161PubMedCrossRefGoogle Scholar
  240. 240.
    Tsuchida Y, Kaneko M, Yokomori K et al (1978) Alpha-fetoprotein, prealbumin, albumin, alpha-1-antitrypsin, and transferrin as diagnostic and therapeutic markers for endodermal sinus tumors. J Pediatr Surg 13:25PubMedCrossRefGoogle Scholar
  241. 241.
    Tsujioka H, Hamada T, Miyakawa H (2003) A pure nongestational choriocarcinoma of the ovary diagnosed with DNA polymorphism analysis. Gynecol Oncol 89:540PubMedCrossRefGoogle Scholar
  242. 242.
    Tsuura Y, Hiraki H, Watanabe K et al (1996) Preferential localization of C-kit product in tissue mast cells, basal cells of skin, epithelial cells of breast, small cell lung carcinoma and seminoma/dysgerminoma in the human. Immunohistochemical study on formalin-fixed paraffin-embedded tissues. Virchows Arch 424:135Google Scholar
  243. 243.
    Ueda G, Fujita M, Ogawa H, Sawada M, Inoue M, Tanizawa O (1993) Adenocarcinoma in a benign cystic teratoma of the ovary. Report of a case with a long survival period. Gynecol Oncol 48:259PubMedCrossRefGoogle Scholar
  244. 244.
    Ulbright TM (2005) Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues. Mod Pathol 18(Suppl 2):S61PubMedCrossRefGoogle Scholar
  245. 245.
    Ulbright TM, Roth LM, Erlich CE (1982) Ovarian strumal carcinoid. An immunocytochemical and ultrastructural study of two cases. Am J Clin Pathol 77:622PubMedGoogle Scholar
  246. 246.
    Ulirsch RC, Goldman RL (1982) An unusual teratoma of the ovary: neurogenic cyst with lactating breast tissue. Obstet Gynecol 60:400PubMedGoogle Scholar
  247. 247.
    Vance RP, Geisinger KR (1985) Pure nongestational choriocarcinoma of the ovary. Report of a case. Cancer (Phila) 56:2321CrossRefGoogle Scholar
  248. 248.
    Vang R, Gown AM, Zhao C et al (2007) Ovarian mucinous tumors associated with mature cystic teratoma. Morphologic and immunohistochemical analysis identifies a subset of potential teratomatous origin that shares features of lower gastrointestinal tract mucinous tumors more commonly encountered as secondary tumors of the ovary. Am J Surg Pathol 31:854PubMedCrossRefGoogle Scholar
  249. 249.
    Warkel RL, Cooper PH, Helwig EB (1978) Adenocarcinoid, a mucin-producing carcinoid of the appendix. Cancer (Phila) 42:2781CrossRefGoogle Scholar
  250. 250.
    Weldon-Linne CM, Rushovich AM (1983) Benign ovarian cystic teratomas with homunculi. Obstet Gynecol 61:88SPubMedGoogle Scholar
  251. 251.
    Williamson HO, Underwood PB Jr, Kreutner A Jr, Rogers JF, Mathur RS, Pratt-Thomas HR (1976) Gonadoblastoma: clinicopathologic correlation in six patients. Am J Obstet Gynecol 126:579PubMedGoogle Scholar
  252. 252.
    Wisniewski M, Deppisch LM (1973) Solid teratomas of the ovary. Cancer (Phila) 32:440CrossRefGoogle Scholar
  253. 253.
    Witschi E (1948) Migration of the germ cells of human embryos from the yolk sac to the primitive gonadal folds. Contrib Embryol 32:69Google Scholar
  254. 254.
    Woodruff JD, Rauh JT, Markley RL (1966) Ovarian struma. Obstet Gynecol 27:194PubMedGoogle Scholar
  255. 255.
    Woodruff JD, Protos P, Peterson WF (1968) Ovarian teratomas. Relationship of histologic and ontogenic factors to prognosis. Am J Obstet Gynecol 102:702PubMedGoogle Scholar
  256. 256.
    Yanai-Inbar I, Scully RE (1987) Relation of ovarian dermoid cysts and immature teratomas: an analysis of 350 cases of immature teratoma and 10 cases of dermoid cyst with microscopic foci of immature tissue. Int J Gynecol Pathol 6:203PubMedCrossRefGoogle Scholar
  257. 257.
    Young RH, Scully RE (1983) Ovarian Sertoli–Leydig cell tumors with a retiform pattern. A problem in histopathologic diagnosis. A report of 25 cases. Am J Surg Pathol 7:755PubMedGoogle Scholar
  258. 258.
    Young RH, Prat J, Scully RE (1982) Ovarian Sertoli–Leydig cell tumors with heterologous elements (1) gastrointestinal epithelium and carcinoid: a clinicopathologic analysis of thirty six cases. Cancer (Phila) 50:2448CrossRefGoogle Scholar
  259. 259.
    Zaloudek C, Tavassoli FA, Norris HJ (1981) Dysgerminoma with syncytiotrophoblastic giant cells. A histologically and clinically distinctive subtype of dysgerminoma. Am J Surg Pathol 5:361PubMedCrossRefGoogle Scholar
  260. 260.
    Zhao S, Kato N, Endoh Y et al (2000) Ovarian gonadoblastoma with mixed germ cell tumor in a woman with 46,XX karyotype and successful pregnancies. Pathol Int 50:332PubMedCrossRefGoogle Scholar
  261. 261.
    Zhao C, Bratthauer GL, Barner R et al (2007) Comparative analysis of alternative and traditional immunohistochemical markers for the distinction of ovarian Sertoli cell tumor from endometrioid tumors and carcinoid tumor: a study of 160 cases. Am J Surg Pathol 31:255PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Surgical PathologyThomas Jefferson University HospitalPhiladelphiaUSA
  2. 2.Department of Pathology, Division of Gynecologic PathologyThe Johns Hopkins Medical InstitutionsBaltimoreUSA

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