Sex Cord-Stromal, Steroid Cell, and Other Ovarian Tumors with Endocrine, Paraendocrine, and Paraneoplastic Manifestations

  • Robert H. YoungEmail author
Reference work entry


This category includes all ovarian neoplasms that contain granulosa cells, fibroblasts, theca cells (and their luteinized derivatives), Sertoli cells, Leydig cells, singly or in various combinations and in varying degrees of differentiation. Those who believe that all these cell types are derived from the “specialized stroma” of the genital ridge favor the term gonadal stromal tumors for these neoplasms [110]. Others, recognizing that many embryologists favor the participation of coelomic and mesonephric epithelium in the formation of sex cords, which are the proximal precursors of granulosa cells and Sertoli cells, favor the term sex cord-stromal tumors, and it is now the most widely accepted designation [144].


Granulosa Cell Ovarian Tumor Leydig Cell Theca Cell Granulosa Cell Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



When the late Dr. Ancel Blaustein prepared the first edition of this book in the mid-1970s, he asked Dr. Robert E. Scully to contribute the chapter on ovarian sex cord-stromal tumors and it duly appeared in 1977. In the 1980s, I had the pleasure and privilege of reviewing numerous sex cord-stromal tumors of the ovary in Dr. Scully’s remarkable collection and a number of original publications with Dr. Scully and others came to pass. This resulted in Dr. Scully asking me if I would co-author the contribution on this topic for the third edition, expanded by the inclusion of consideration of steroid cell tumors and a variety of miscellaneous other neoplasms associated with various interesting clinical manifestations. This chapter appeared in the 1987 third edition. Dr. Scully, being retired, declined to participate in this most recent reedition of the chapter and although many of the words were initially written, or edited by him, given his customary awareness of the importance of ethics in medicine, he declined to have his name associated with a work which he did not actively participate in at this time. However, I would like to acknowledge my debt to Dr. Scully for the initial chapter, which laid the groundwork for everything to follow, the opportunity to learn from his cases, and most important of all, to be educated by him on the remarkable and fascinating microscopic spectrum encountered within the family of tumors reviewed in this chapter. Similar remarks pertain to  Chap. 18, Metastatics Tumors of the Ovary.


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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Anatomic PathologyJames Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical SchoolBostonUSA

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