Phosphoinositide 3-Kinase, Fig. 5From: Phosphoinositide 3-KinaseVarious mechanisms identified in cancer cells that result in elevated cellular PIP3 levels. Components in green represent protein products of oncogenes that display gain-of-function in cancer. Components in red represent tumor suppressors that display loss-of-function in cancer. FOXO proteins are transcription factors that promote cell cycle arrest and apoptosisBack to chapter page