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TRP (Transient Receptor Potential Cation Channel)

  • Reference work entry
Encyclopedia of Signaling Molecules

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Synonyms

Ankyrine-rich TRP channel, ANKTM1, TRPA1; Classic TRP channels, TRPC1-7; Melastatin-like TRP channels, TRPM1-8; Mucolipins, TRPML1-3; Polycystines, TRPPs; TRP; TRPL; Vanilloid-like TRP channels, TRPV1-6

Historical Background

Calcium is integrated in many physiological processes like muscle contraction, hormone secretion, and intracellular signaling processes (calcium signaling). Prerequisite for this role is the 10,000-fold gradient across the plasma membrane with 2.5 mM extracellular and resting intracellular calcium ion concentration of approximately 100 nM. Calcium ATPases (Plasma membrane calcium-transporting ATPase) and transporters manage the extrusion of calcium whereas calcium-permeable ion channels enable rapid increases in intracellular calcium up to micromolar concentrations. The biological functions of calcium are mediated by direct calcium binding of the modulated proteins or by protein–protein interaction with calcium sensor proteins (calmodulin, CaBP,...

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References

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Authors and Affiliations

  1. Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology, Interfaculty Center of Pharmacogenomics and Pharmaceutical Research (ICePhA), Eberhard-Karls-University, Wilhelmstraße 56, 72074, Tübingen, Germany

    Dr. Christian Harteneck

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  1. Dr. Christian Harteneck
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Correspondence to Christian Harteneck .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Harteneck, C. (2012). TRP (Transient Receptor Potential Cation Channel). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0461-4_72

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