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TLR5

  • Reference work entry
Encyclopedia of Signaling Molecules

  • 215 Accesses

Synonyms

Myd88: Myeloid differentiation primary response gene (88); Toll-like receptor 5; TRIF: TIR domain–containing adaptor-inducing interferon β

Introduction

An infected host can quickly recognize an invading pathogen via germ-line-encoded pattern recognition receptors (PRRs) that detect microbe-associated molecular patterns (MAMPs) commonly expressed by many pathogens. Recognition of MAMPs by their corresponding receptor allows the host to initiate a rapid inflammatory response that can limit initial pathogen replication (Janeway and Medzhitov 2002). At least four different groups of PRRs have been described with varying cellular location and ligand specificity. Toll-like receptors (TLRs) and C-type lectin receptors (CLRs) are membrane-associated, while RIG-I-like receptors (RLRs) and NOD-like receptors (NLRs) are found in the cytosol. Among the 13 known TLRs, only TLR5 and TLR11 exclusively recognize protein microbial ligands (Kawai and Akira 2010). TLR5 detects flagellin, a...

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Authors and Affiliations

  1. Center for Comparative Medicine, University of California Davis, 4610 X Street, Davis, CA, 95616, USA

    Dr. Shaikh M. Atif & Prof. Stephen J. McSorley

Authors
  1. Dr. Shaikh M. Atif
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  2. Prof. Stephen J. McSorley
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Correspondence to Shaikh M. Atif .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Atif, S.M., McSorley, S.J. (2012). TLR5. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0461-4_639

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