Encyclopedia of Signaling Molecules

2012 Edition
| Editors: Sangdun Choi

TRAF6

Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-0461-4_635

Synonyms

Historical Background

TRAF Family

Tumor necrosis factor receptor-associated factors 1 and 2 (TRAFs) were initially identified as adaptor proteins that associate with the type-2 tumor necrosis factor (TNF) receptor (TNF-R2) (Cao et al. 1996; Ishida et al. 1996; Rothe et al. 1994). The TRAF family members play important roles in the signal transduction cascades that regulate inflammatory responses via nuclear factor kappa-light-chain-enhancer of activated B cells (  NF-κB) and mitogen-activated protein kinases (MAPKs) that are initiated by activated cell surface receptors, such as TNF-R, interleukin 1 receptor (IL-1R), and Toll-like receptors (TLRs). The TRAFs have different cellular and physiological functions despite of their conserved C-terminal domain found in TRAF1-6 (Fig.  1)....
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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Medical Biosciences, Department of PathologyUmeå UniversityUmeåSweden
  2. 2.Ludwig Institute for Cancer ResearchUppsala UniversityUppsalaSweden