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VAMP1/2/3/7

  • Reference work entry
Encyclopedia of Signaling Molecules

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Overview

Intracellular membrane trafficking in eukaryotes is a multiple-step process that can be artificially divided in the budding of vesicles from a donor compartment, their translocation into the cytoplasm along cytoskeletal elements, their tethering and subsequent fusion with the membrane of the target compartment. Membrane fusion involves SNARE proteins, classified into two categories, vesicular (v)-SNAREs and target (t)-SNAREs present on the acceptor membrane. It is the specific pairing of v-SNAREs with their cognate t-SNAREs in trans that is responsible for bringing the lipid bilayers together for membrane fusion and the zippering of SNAREs provides the required energy (Fig. 1). This review focus on the discovery of SNAREs and then on four of the nine v-SNAREs: the clostridial neurotoxin sensitive VAMPs 1, 2, and 3 and on Tetanus neurotoxin-Insensitive Vesicle-Associated Membrane Protein, TI-VAMP/VAMP7. VAMP7, unlike the first ones, possess a long amino-terminal domain called...

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Acknowledgments

We apologize to all the authors that are not cited in the text due to strict reference limitation, we have cited very few reviews on the topic and only the most recent papers that were not cited in these. Our work is supported in part by grants from the Institut National de la Santé et de la Recherche Médicale (INSERM) and the Centre National de la Recherche Scientifique (CNRS), the Association pour la Recherche sur le Cancer (ARC), the Association Française contre les Myopathies (AFM), the Fondation pour la Recherche Médicale (FRM), the Mairie de Paris Medical Research and Health Program, Fédération pour la Recherche sur le Cerveau (FRC), and the Ecole des Neurosciences de Paris-Ile de France (ENP).

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Authors and Affiliations

  1. Membrane Traffic in Neuronal & Epithelial Morphogenesis, INSERM ERL U950, Paris, F-75013, France

    Dr. Thierry Galli & Dr. Véronique Proux-Gillardeaux

  2. Program in Development & Neurobiology, Jacques Monod Institute, CNRS UMR7592, Paris, F-75013, France

    Dr. Thierry Galli & Dr. Véronique Proux-Gillardeaux

  3. University Denis Diderot–Paris 7, Paris, F-75013, France

    Dr. Thierry Galli & Dr. Véronique Proux-Gillardeaux

  4. Membrane Traffic in Neuronal and Epithelial Morphogenesis; Program in Development, Jacques Monod Institute CNRS UMR7592, Equipe INSERM ERL U950, CNRS & Univ. Denis Diderot/Paris 7, Bat. Buffon, 3rd floor–15 rue Hélène Brion, 75205, Paris, Cedex 13, France

    Dr. Véronique Proux-Gillardeaux

Authors
  1. Dr. Thierry Galli
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  2. Dr. Véronique Proux-Gillardeaux
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Correspondence to Véronique Proux-Gillardeaux .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Galli, T., Proux-Gillardeaux, V. (2012). VAMP1/2/3/7. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0461-4_627

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