Endothelin A Receptor (ETAR)
Endothelin-1 (ET-1) is a 21-amino-acid vasoactive peptide (see structure in Table 1) that was first isolated and identified in 1988 from porcine aortic endothelial cells. The endothelin family consists of three isoforms: ET-1, ET-2, and ET-3. ET-1 is the principal isoform and is a very potent vasoconstrictor and growth promoter. The physiological effects of the ET system are many and include regulation of vascular tone, renal function, and cell proliferation. ET exerts its effects through two types of endothelin receptors: type A (ETAR) and type B (ETBR). ETAR and ETBR are G-protein-coupled receptors (GPCRs) that share homology with the rhodopsin family. ETAR is pharmacologically distinguished...
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