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Toll-like Receptor Adaptor Protein Family Members

  • Reference work entry
Encyclopedia of Signaling Molecules

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Synonyms

Mal: Myd88-adapter-like; TLR4AP; TIRAP; Toll-interleukin 1 receptor (TIR) domain-containing adapter protein; Toll-like receptor 4 adapter protein; Wyatt

MyD88: Myeloid differentiation primary response gene 88

SARM: MyD88-5; Sterile alpha and TIR motif-containing protein

TRIF: TICAM-1; TIR-domain-containing adapter molecule 1; TIR-domain-containing adapter protein inducing IFN-beta; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta

TRAM: TICAM-2; TIRP; TIR-domain-containing adapter molecule 2; TRIF-related adapter molecule; Toll-like receptor adaptor protein 3; Toll/interleukin-1 receptor domain-containing protein

Historical Background

Toll-like receptors (TLRs) play a critical role in innate immunity by providing a frontline defense mechanism against invading pathogens such as bacteria, fungi and viruses. They accomplish this by recognising evolutionarily conserved pathogen-associated molecular patterns (PAMPs) which are unique to pathogens...

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Authors and Affiliations

  1. Department of Biology, Institute of Immunology, National University of Ireland Maynooth, Maynooth, Maynooth, Co. Kildare, Ireland

    Dr. Enda Shevlin & Sinéad M. Miggin

Authors
  1. Dr. Enda Shevlin
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  2. Sinéad M. Miggin
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Corresponding author

Correspondence to Sinéad M. Miggin .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Shevlin, E., Miggin, S.M. (2012). Toll-like Receptor Adaptor Protein Family Members. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0461-4_608

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