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RhoC (RHOC)

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Encyclopedia of Signaling Molecules

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References

  • Arthur WT, Ellerbroek SM, et al. XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. J Biol Chem. 2002;277(45):42964–72.

    Article  PubMed  CAS  Google Scholar 

  • Bellovin DI, Simpson KJ, et al. Reciprocal regulation of RhoA and RhoC characterizes the EMT and identifies RhoC as a prognostic marker of colon carcinoma. Oncogene. 2006;25(52):6959–67.

    Article  PubMed  CAS  Google Scholar 

  • Bos JL, Rehmann H, et al. GEFs and GAPs: critical elements in the control of small G proteins. Cell. 2007;129(5):865–77.

    Article  PubMed  CAS  Google Scholar 

  • Boureux A, Vignal E, et al. Evolution of the Rho family of ras-like GTPases in eukaryotes. Mol Biol Evol. 2007;24(1):203–16.

    Article  PubMed  CAS  Google Scholar 

  • Bravo-Cordero JJ, Oser M, et al. A novel spatiotemporal RhoC activation pathway locally regulates cofilin activity at invadopodia. Curr Biol. 2011;21(8):635–44.

    Article  PubMed  CAS  Google Scholar 

  • Chen Y, Yang Z, et al. Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement. Mol Cell. 2009;35(6):841–55.

    Article  PubMed  CAS  Google Scholar 

  • Clark EA, Golub TR, et al. Genomic analysis of metastasis reveals an essential role for RhoC. Nature. 2000;406(6795):532–5.

    Article  PubMed  CAS  Google Scholar 

  • Dietrich KA, Schwarz R, et al. Specific induction of migration and invasion of pancreatic carcinoma cells by RhoC, which differs from RhoA in its localisation and activity. Biol Chem. 2009;390(10):1063–77.

    Article  PubMed  CAS  Google Scholar 

  • Ellerbroek SM, Wennerberg K, et al. Serine phosphorylation negatively regulates RhoA in vivo. J Biol Chem. 2003;278(21):19023–31.

    Article  PubMed  CAS  Google Scholar 

  • Faried A, Faried LS, et al. RhoA and RhoC proteins promote both cell proliferation and cell invasion of human oesophageal squamous cell carcinoma cell lines in vitro and in vivo. Eur J Cancer. 2006;42(10):1455–65.

    Article  PubMed  CAS  Google Scholar 

  • Giampieri S, Manning C, et al. Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility. Nat Cell Biol. 2009;11(11):1287–96.

    Article  PubMed  CAS  Google Scholar 

  • Hakem A, Sanchez-Sweatman O, et al. RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis. Genes Dev. 2005;19(17):1974–9.

    Article  PubMed  CAS  Google Scholar 

  • Iiizumi M, Bandyopadhyay S, et al. RhoC promotes metastasis via activation of the Pyk2 pathway in prostate cancer. Cancer Res. 2008;68(18):7613–20.

    Article  PubMed  CAS  Google Scholar 

  • Jaffe AB, Hall A. Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol. 2005;21:247–69.

    Article  PubMed  CAS  Google Scholar 

  • Jiang L, Liu X, et al. Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma. Int J Cancer. 2010;127(3):505–12.

    Article  PubMed  CAS  Google Scholar 

  • Karlsson R, Pedersen ED, et al. Rho GTPase function in tumorigenesis. Biochim Biophys Acta. 2009;1796(2):91–8.

    PubMed  CAS  Google Scholar 

  • Kitzing TM, Wang Y, et al. Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC. Oncogene. 2010;29(16):2441–8.

    Article  PubMed  CAS  Google Scholar 

  • Lochhead PA, Wickman G, et al. Activating ROCK1 somatic mutations in human cancer. Oncogene. 2010;29(17):2591–8.

    Article  PubMed  CAS  Google Scholar 

  • Ma L, Teruya-Feldstein J, et al. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature. 2007;449(7163):682–8.

    Article  PubMed  CAS  Google Scholar 

  • Madaule P, Axel R. A novel ras-related gene family. Cell. 1985;41(1):31–40.

    Article  PubMed  CAS  Google Scholar 

  • Merajver SD, Usmani SZ. Multifaceted role of Rho proteins in angiogenesis. J Mammary Gland Biol Neoplasia. 2005;10(4):291–8.

    Article  PubMed  Google Scholar 

  • Spangler B, Kappelmann M et al. ETS-1/RhoC signaling regulates the transcription factor c-Jun in melanoma. Int J Cancer. 2011

    Google Scholar 

  • Sun HW, Tong SL, et al. RhoA and RhoC -siRNA inhibit the proliferation and invasiveness activity of human gastric carcinoma by Rho/PI3K/Akt pathway. World J Gastroenterol. 2007;13(25):3517–22.

    PubMed  CAS  Google Scholar 

  • Vega FM, Ridley AJ. Rho GTPases in cancer cell biology. FEBS Lett. 2008;582(14):2093–101.

    Article  PubMed  CAS  Google Scholar 

  • Vega FM, Fruhwirth G, et al. RhoA and RhoC have distinct roles in migration and invasion by acting through different targets. J Cell Biol. 2011;193(4):655–65.

    Article  PubMed  CAS  Google Scholar 

  • Wang W, Wu F, et al. RhoC is essential for angiogenesis induced by hepatocellular carcinoma cells via regulation of endothelial cell organization. Cancer Sci. 2008;99(10):2012–18.

    PubMed  CAS  Google Scholar 

  • Wheeler AP, Ridley AJ. Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility. Exp Cell Res. 2004;301(1):43–9.

    Article  PubMed  CAS  Google Scholar 

  • Wu M, Wu ZF, et al. Characterization of the roles of RHOC and RHOA GTPases in invasion, motility, and matrix adhesion in inflammatory and aggressive breast cancers. Cancer. 2010;116(11 Suppl):2768–82.

    Article  PubMed  CAS  Google Scholar 

  • Wu Y, Chen YC, et al. RhoC protein stimulates migration of gastric cancer cells through interaction with scaffold protein IQGAP1. Mol Med Rep. 2011;4(4):697–703.

    CAS  Google Scholar 

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Correspondence to Anne J. Ridley .

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Reymond, N., Vega, F.M., Ridley, A.J. (2012). RhoC (RHOC). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0461-4_59

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