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Encyclopedia of Signaling Molecules pp 1424–1429Cite as

Pin1

  • Reference work entry

  • 64 Accesses

Synonyms

Peptidyl-prolyl cis-trans Isomerase NIMA-interacting 1; Peptidyl-prolyl cis-trans Isomerase Pin1; Rotamase Pin1

Historical Background

Pin1 is a phosphorylation-dependent peptidyl-prolyl isomerase that was first isolated by a yeast two-hybrid screen designed to identify human proteins which interact with the “Never in Mitosis” gene A (NIMA) (Lu et al. 1996). Sequence analysis revealed that human Pin1 exhibits approximately 45% sequence similarity with the product of the ESS1 gene which was previously identified as essential for growth in the budding yeast Saccharomyces cerevisiae (Hanes et al. 1989). It has subsequently been found that Pin1-like proteins are highly conserved, found in both eukaryotes and prokaryotes (Maruyama et al. 2004). While it was initially implicated as a regulator of mitosis, it is evident that Pin1 has roles in a number of biological processes.

Pin1 is classified as a peptidyl-prolyl isomerase (PPIase), catalyzing the cis-trans conversion of the peptide...

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References

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Author information

Authors and Affiliations

  1. Department of Biochemistry, Schulich School of Medicine & Dentistry, The University of Western Ontario, Medical Sciences Building, M342C, London, ON, N6A 5C1, Canada

    Dana Onica & Prof. David W. Litchfield

  2. Department of Oncology, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, ON, Canada

    Prof. David W. Litchfield

Authors
  1. Dana Onica
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  2. Prof. David W. Litchfield
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Corresponding author

Correspondence to David W. Litchfield .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Onica, D., Litchfield, D.W. (2012). Pin1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0461-4_581

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