Encyclopedia of Signaling Molecules

2012 Edition
| Editors: Sangdun Choi


  • Dana Onica
  • David W. Litchfield
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-0461-4_581


Historical Background

Pin1 is a phosphorylation-dependent peptidyl-prolyl isomerase that was first isolated by a yeast two-hybrid screen designed to identify human proteins which interact with the “Never in Mitosis” gene A (NIMA) (Lu et al. 1996). Sequence analysis revealed that human Pin1 exhibits approximately 45% sequence similarity with the product of the ESS1 gene which was previously identified as essential for growth in the budding yeast Saccharomyces cerevisiae (Hanes et al. 1989). It has subsequently been found that Pin1-like proteins are highly conserved, found in both eukaryotes and prokaryotes (Maruyama et al. 2004). While it was initially implicated as a regulator of mitosis, it is evident that Pin1 has roles in a number of biological processes.

Pin1 is classified as a peptidyl-prolyl isomerase (PPIase), catalyzing the cis-trans conversion of the...
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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of BiochemistrySchulich School of Medicine & Dentistry, The University of Western OntarioLondonCanada
  2. 2.Department of Oncology, Schulich School of Medicine & DentistryThe University of Western OntarioLondonCanada