Encyclopedia of Signaling Molecules

2012 Edition
| Editors: Sangdun Choi

TPD52 (Tumor Protein D52)

  • Austin Della-Franca
  • Yuyan Chen
  • Jennifer Anne Byrne
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-0461-4_555


Historical Background and Overview

Mammalian TPD52 sequences were first reported in the mid-1990s, through a number of independent approaches. Two early reports identified TPD52 sequences through their increased expression in human cancer tissue or cell lines, relative to either nonmalignant tissues or fibroblast cell lines. Orthologous sequences from other species were identified as proteins phosphorylated in response to increased intracellular calcium, or as a retroviral target gene. Early reports also highlighted the existence of paralogous sequences in human and mouse, and TPD52 is now known to be part of a four-member mammalian gene family. While TPD52-like sequences are well conserved both within and between species, they show little homology with those of other proteins.

Human TPD52 isoforms are approximately 200 residues in length,...
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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Austin Della-Franca
    • 1
  • Yuyan Chen
    • 1
  • Jennifer Anne Byrne
    • 1
  1. 1.Children’s Cancer Research Unit, Kids Research InstituteThe Children’s Hospital at WestmeadWestmeadAustralia