TPD52 (Tumor Protein D52)
Historical Background and Overview
Mammalian TPD52 sequences were first reported in the mid-1990s, through a number of independent approaches. Two early reports identified TPD52 sequences through their increased expression in human cancer tissue or cell lines, relative to either nonmalignant tissues or fibroblast cell lines. Orthologous sequences from other species were identified as proteins phosphorylated in response to increased intracellular calcium, or as a retroviral target gene. Early reports also highlighted the existence of paralogous sequences in human and mouse, and TPD52 is now known to be part of a four-member mammalian gene family. While TPD52-like sequences are well conserved both within and between species, they show little homology with those of other proteins.
- Natrajan R, Weigelt B, Mackay A, Geyer FC, Grigoriadis A, Tan DS, et al. An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancers. Breast Cancer Res Treat. 2010;121:575–89.PubMedGoogle Scholar