Encyclopedia of Signaling Molecules

2012 Edition
| Editors: Sangdun Choi

TBCCD1

Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-0461-4_551

Historical Background

The major microtubule organizing center in animal cells is the centrosome which consists of a pair of centrioles surrounded by the pericentriolar matrix. In interphase cells, centrosomes nucleate and organize the microtubule cytoskeleton and are usually maintained at the cell center in close association with the nucleus (Bettencourt-Dias and Glover 2007). This association constitutes a primordial axis of cytoplasmic compartments organization and organelle positioning (e.g., ER and Golgi apparatus). Centrosomes are also involved in mitotic spindle formation, and an aberrant centrosome number has been linked to multipolar spindles and to cancer cells. In the last years, the ability of centrosomes to become basal bodies and assemble cilia emerged also as a critical role (Bettencourt-Dias and Glover 2007). Cilia are now established as having important roles as movement generating and sensory organeles being essential for embryonic development. Critically, cilia...

This is a preview of subscription content, log in to check access.

References

  1. Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M. Proteomic characterization of the human centrosome by protein correlation profiling. Nature. 2003;426(6966):570–4.PubMedGoogle Scholar
  2. Archambault V, Zhao X, White-Cooper H, Carpenter ATC, Glover DM. Mutations in Drosophila Greatwall/Scant reveal its roles in mitosis and meiosis and interdependence with Polo kinase. PLoS Genet. 2007;3(11):e200.PubMedGoogle Scholar
  3. Bartolini F, Bhamidipati A, Thomas S, Schwahn U, Lewis SA, Cowan NJ. Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C. J Biol Chem. 2002;277:14629–34.PubMedGoogle Scholar
  4. Bettencourt-Dias M, Glover DM. Centrosome biogenesis and function: centrosomics brings new understanding. Nat Rev Mol Cell Biol. 2007;8:451–63.PubMedGoogle Scholar
  5. Buch C, Lindberg R, Figueroa R, Gudise S, Onischenko E, Hallberg E. An integral protein of the inner nuclear membrane localizes to the mitotic spindle in mammalian cells. J Cell Sci. 2009;122:2100–7.PubMedGoogle Scholar
  6. Burakov A, Nadezhdina E, Slepchenko B, Rodionov V. Centrosome positioning in interphase cells. J Cell Biol. 2003;162:963–9.PubMedGoogle Scholar
  7. Chevrier V, Piel M, Collomb N, Saoudi Y, Frank R, Paintrand M, Narumiya S, Bornens M. Job D The Rho-associated protein kinase p160ROCK is required for centrosome positioning. J Cell Biol. 2002;157:807–17.PubMedGoogle Scholar
  8. Cuvillier A, Redon F, Antoine JC, Chardin P, DeVos T, Merlin G. LdARL-3A, a Leishmania promastigote-specific ADP-ribosylation factor-like protein, is essential for flagellum integrity. J Cell Sci. 2000;113:2065–74.PubMedGoogle Scholar
  9. Feldman JL, Marshall WF. ASQ2 Encodes a TBCC-like protein required for mother-daughter centriole linkage and mitotic spindle orientation. Curr Biol. 2009;19:1238–43.PubMedGoogle Scholar
  10. Fontalba A, Paciucci R, Avila J, Zabala JC. Incorporation of tubulin subunits into dimers requires GTP hydrolysis, J. Cell Sci. 1993;106:627–32.Google Scholar
  11. Gonçalves J, Nolasco S, Nascimento R, Lopez Fanarraga M, Zabala JC, Soares H. TBCCD1, a new centrosomal protein is required for centrosome and Golgi apparatus positioning. EMBO Rep. 2010;11:194–200.PubMedGoogle Scholar
  12. Keller LC, Romijn EP, Zamora I, Yates JR 3rd, Marshall WF. Proteomic analysis of isolated chlamydomonas centrioles reveals orthologs of ciliary-disease genes. Curr Biol. 2005;15(12):1090–8.PubMedGoogle Scholar
  13. Lopez-Fanarraga M, Avila J, Guasch A, Coll M, Zabala JC. Review: postchaperonin tubulin folding cofactors and their role in microtubule dynamics. J Struct Biol. 2001;135:219–29.PubMedGoogle Scholar
  14. Malone CJ, Misner L, Le Bot N, Tsai MC, Campbell JM, Ahringer J, White JG. The C. elegans hook protein, ZYG-12, mediates the essential attachment between the centrosome and nucleus. Cell. 2003;115:825–36.PubMedGoogle Scholar
  15. Nigg EA, Raff JW. Centrioles, centrosomes and cilia in health and disease. Cell. 2009;139:663–78.PubMedGoogle Scholar
  16. Pouthas F, Girard P, Lecaudey V, Ly TB, Gilmour D, Boulin C, Pepperkok R. Reynaud EG In migrating cells, the Golgi complex and the position of the centrosome depend on geometrical constraints of the substratum. J Cell Sci. 2008;121:2406–14.PubMedGoogle Scholar
  17. Salpingidou G, Smertenko A, Hausmanowa-Petrucewicz I, Hussey PJ, Hutchison CJ. A novel role for the nuclear membrane protein emerin in association of the centrosome to the outer nuclear membrane. J Cell Biol. 2007;178:897–04.PubMedGoogle Scholar
  18. Schrick JJ, Vogel P, Abuin A, Hampton B, Rice DS. ADP-ribosylation factor-like 3 is involved in kidney and photoreceptor development. Am J Pathol. 2006;168:1288–98.PubMedGoogle Scholar
  19. Schwahn U, Lenzner S, Dong J, Feil S, Hinzmann B, van Duijnhoven G, Kirschner R, Hemberger M, Bergen AA, Rosenberg T, Pinckers AJ, Fundele R, Rosenthal A, Cremers FP, Ropers HH, Berger W. Positional cloning of the gene for X-linked retinitis pigmentosa 2. Nat Genet. 1998;19:327–32.PubMedGoogle Scholar
  20. Tian G, Bhamidipati A, Cowan NJ, Lewis SA. Tubulin folding cofactors as GTPase-ctivating proteins. GTP hydrolysis and the assembly of the alpha/beta-tubulin heterodimer. J Biol Chem. 1999;274:24054–8.PubMedGoogle Scholar
  21. Veltel S, Gasper R, Eisenacher E, Wittinghofer A. The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3. Nat Struct Mol Biol. 2008;15:373–80.PubMedGoogle Scholar
  22. Zhou C, Cunningham L, Marcus AI, Li Y, Kahn RA. Arl2 and Arl3 regulate different microtubule-dependent processes. Mol Biol Cell. 2006;17:2476–87.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Centro de Química e BioquímicaLisbonPortugal
  2. 2.Instituto Gulbenkian de CiênciaOeirasPortugal
  3. 3.Escola Superior de Tecnologia da Saúde de LisboaLisboaPortugal
  4. 4.Centro de Química e Bioquímica, Faculdade de CiênciasUniversidade de LisboaLisboaPortugal