The major microtubule organizing center in animal cells is the centrosome which consists of a pair of centrioles surrounded by the pericentriolar matrix. In interphase cells, centrosomes nucleate and organize the microtubule cytoskeleton and are usually maintained at the cell center in close association with the nucleus (Bettencourt-Dias and Glover 2007). This association constitutes a primordial axis of cytoplasmic compartments organization and organelle positioning (e.g., ER and Golgi apparatus). Centrosomes are also involved in mitotic spindle formation, and an aberrant centrosome number has been linked to multipolar spindles and to cancer cells. In the last years, the ability of centrosomes to become basal bodies and assemble cilia emerged also as a critical role (Bettencourt-Dias and Glover 2007). Cilia are now established as having important roles as movement generating and sensory organeles being essential for embryonic development. Critically, cilia...
- Fontalba A, Paciucci R, Avila J, Zabala JC. Incorporation of tubulin subunits into dimers requires GTP hydrolysis, J. Cell Sci. 1993;106:627–32.Google Scholar
- Schwahn U, Lenzner S, Dong J, Feil S, Hinzmann B, van Duijnhoven G, Kirschner R, Hemberger M, Bergen AA, Rosenberg T, Pinckers AJ, Fundele R, Rosenthal A, Cremers FP, Ropers HH, Berger W. Positional cloning of the gene for X-linked retinitis pigmentosa 2. Nat Genet. 1998;19:327–32.PubMedGoogle Scholar