TRAIL Receptor 1/2 (Death Receptor 4/5, DR4/5)
The tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL, Apo2L) identified in the middle of 1990s (Pitti et al. 1996; Wiley et al. 1995) was given its name due to its ability of inducing apoptosis and its high homology to other TNF member ligands. Then, its first receptor, death receptor 4 (DR4, TRAIL-R1), was identified by searching an EST database for sequences related to the TNF receptor-1 (TNFR1) death domain (DD) (Pan et al. 1997b). Thereafter, by virtue of its sequence homology to the DR4 DD, death receptor 5 (DR5, TRAIL-R2) was also cloned independently by two groups (MacFarlane et al. 1997; Walczak et al. 1997). Both DR4 and DR5 are belonging to members of the TNF receptor superfamily (TNFRSF). However, unlikely with TNFRSF receptors containing the intracellular DD, such as...
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