TMEM85 (Transmembrane Protein 85)
Prior to 2008, there were no publications on the TMEM85 gene or protein. The GenBank and Entrez Gene databases described TMEM85 as an evolutionary conserved transmembrane domain containing protein (DUF1077 superfamily motif) found in all eukaryotes examined (TMEM85-gene). In the yeast Saccharomyces cerevisiae, the TMEM85 orthologue is called YGL231c. In 2003, it was reported that yeast cells lacking YGL231c showed an increased sensitivity to the toxic effects of ectopically expressed Parkinson’s disease associated gene α-synuclein (Willingham et al. 2003). Finally, the analysis of a GFP tagged genomic copy of YGL231c suggests that the protein is a resident of the endoplasmic reticulum (ER) (YGL231c-gene).
TMEM85, an Anti-apoptotic Gene
By screening a human heart cDNA expression library in yeast cell undergoing apoptosis due to the ectopic expression of a cDNA encoding the pro-apoptotic...
- Saccharomyces Genome Database for the YGL231c gene. http://www.yeastgenomeorg/cgi-bin/locusfpl?locus=YGL231C. Accessed 5 April 2011.
- The Entez Gene web page for the TMEM85 gene. http://www.ncbinlmnihgov/gene/51234. Accessed 5 April 2011.
- The Universal Protein Resource (UniProt) web page for the human TMM85 protein http://www.uniprot.org/uniprot/Q5J8M3. Accessed 5 April 2011.