Encyclopedia of Signaling Molecules

2012 Edition
| Editors: Sangdun Choi

TMEM85 (Transmembrane Protein 85)

Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-0461-4_532


Historical Background

Prior to 2008, there were no publications on the TMEM85 gene or protein. The GenBank and Entrez Gene databases described TMEM85 as an evolutionary conserved transmembrane domain containing protein (DUF1077 superfamily motif) found in all eukaryotes examined (TMEM85-gene). In the yeast Saccharomyces cerevisiae, the TMEM85 orthologue is called YGL231c. In 2003, it was reported that yeast cells lacking YGL231c showed an increased sensitivity to the toxic effects of ectopically expressed Parkinson’s disease associated gene α-synuclein (Willingham et al. 2003). Finally, the analysis of a GFP tagged genomic copy of YGL231c suggests that the protein is a resident of the endoplasmic reticulum (ER) (YGL231c-gene).

TMEM85, an Anti-apoptotic Gene

By screening a human heart cDNA expression library in yeast cell undergoing apoptosis due to the ectopic expression of a cDNA encoding the pro-apoptotic...

This is a preview of subscription content, log in to check access.


  1. Bossers K, Meerhoff G, Balesar R, van Dongen JW, Kruse CG, Swaab DF, Verhaagen J. Analysis of gene expression in Parkinson’s disease: possible involvement of neurotrophic support and axon guidance in dopaminergic cell death. Brain Pathol. 2009;19:91–107.PubMedGoogle Scholar
  2. Greenwood MT, Ludovico P. Expressing and functional analysis of mammalian apoptotic regulators in yeast. Cell Death Differ. 2010;17:737–45.PubMedGoogle Scholar
  3. Jonikas MC, Collins SR, Denic V, Oh E, Quan EM, Schmid V, Weibezahn J, Schwappach B, Walter P, Weissman JS, Schuldiner M. Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science. 2009;323:1693–7.PubMedGoogle Scholar
  4. Ring G, Khoury CM, Solar AJ, Yang Z, Mandato CA, Greenwood MT. Transmembrane protein 85 from both human (TMEM85) and yeast (YGL231c) inhibit hydrogen peroxide mediated cell death in yeast. FEBS Lett. 2008;582:2637–42.PubMedGoogle Scholar
  5. Saccharomyces Genome Database for the YGL231c gene. http://www.yeastgenomeorg/cgi-bin/locusfpl?locus=YGL231C. Accessed 5 April 2011.
  6. The Entez Gene web page for the TMEM85 gene. http://www.ncbinlmnihgov/gene/51234. Accessed 5 April 2011.
  7. The Universal Protein Resource (UniProt) web page for the human TMM85 protein http://www.uniprot.org/uniprot/Q5J8M3. Accessed 5 April 2011.
  8. Willingham S, Outeiro TF, DeVit MJ, Lindquist SL, Muchowski PJ. Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. Science. 2003;302:1769–72.PubMedGoogle Scholar
  9. Yan Z, Lathia KB, Clapshaw PA. Murine spinal cord transcriptome analysis following reduction of prevalent myelin cDNA sequences. Cell Mol Neurobiol. 2009;29:1109–19.PubMedGoogle Scholar
  10. Zheng J, Anderson CT, Miller KK, Cheatham M, Dallos P. Identifying components of the hair-cell interactome involved in cochlear amplification. BMC Genomics. 2009;10:127.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Chemistry and Chemical EngineeringRoyal Military College of CanadaKingstonCanada