PCAF Lysine Acetyltransferase
Historical Background: Identification of PCAF as an Acetyltransferase
Human PCAF was identified in the mid-1990s based on an analogy between yeast and mammalian transcriptional control systems (Yang et al. 1996). In the budding yeast Saccharomyces cerevisiae, amino acid starvation results in derepression of expression of enzymes for different biosynthetic pathways. This phenomenon suggests co-regulation of different pathways and is thus referred to as “general control of amino acid biosynthesis” (Hinnebusch and Fink 1983; Thireos et al. 1984). Genetic screens in the late 1970s and early 1980s uncovered various mutant strains with defects in the gene control response (Hinnebusch and Fink 1983). Responsible genes of two such mutant strains were named Gcn4 (general control non-derepressible 4, also referred to as amino acid analog-sensitive 3, Aas3 or Aas101) and Gcn5...
This research was supported by operating grants from CIHR and Canadian Cancer Society (to X.J.Y.).
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