Encyclopedia of Signaling Molecules

2012 Edition
| Editors: Sangdun Choi

PCAF Lysine Acetyltransferase

Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-0461-4_511

Synonyms

Historical Background: Identification of PCAF as an Acetyltransferase

Human PCAF was identified in the mid-1990s based on an analogy between yeast and mammalian transcriptional control systems (Yang et al. 1996). In the budding yeast Saccharomyces cerevisiae, amino acid starvation results in derepression of expression of enzymes for different biosynthetic pathways. This phenomenon suggests co-regulation of different pathways and is thus referred to as “general control of amino acid biosynthesis” (Hinnebusch and Fink 1983; Thireos et al. 1984). Genetic screens in the late 1970s and early 1980s uncovered various mutant strains with defects in the gene control response (Hinnebusch and Fink 1983). Responsible genes of two such mutant strains were named Gcn4 (general control non-derepressible 4, also referred to as amino acid analog-sensitive 3, Aas3 or Aas101) and Gcn5...

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Notes

Acknowledgments

This research was supported by operating grants from CIHR and Canadian Cancer Society (to X.J.Y.).

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© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.The Rosalind & Morris Goodman Cancer Research CenterMcGill UniversityMontréalCanada
  2. 2.Departments of Biochemistry and Anatomy & MedicineMcGill University Health CenterMontréalCanada
  3. 3.Departments of MedicineMcGill University Health CenterMontréalCanada