Encyclopedia of Signaling Molecules

2012 Edition
| Editors: Sangdun Choi


Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-0461-4_51


Historical Background

Control of protein translation is a universal checkpoint that enables eukaryotic cells to respond to environmental challenge. Accordingly, it had been noted that virus infection halted host protein synthesis, and it was established that viral double-stranded (ds) RNA provoked this effect. A protein kinase, now designated PKR, was identified which phosphorylated the translation initiation factor 2α that accounted for this effect. It was subsequently demonstrated that this kinase was induced by interferon (IFN), establishing this enzyme as an effector molecule for the central antiviral response. It was subsequently shown...

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Centre for Cancer ResearchMonash Institute of Medical Research, Monash UniversityClaytonAustralia