Double-stranded RNA-activated protein kinase; EIF2A protein kinase 2; Interferon-inducible eIF2α kinase; Interferon-inducible RNA-dependent protein kinase; P1/eIF2A protein kinase; p68 kinase, dsRNA-activated inhibitor (DAI); Protein kinase interferon-induced double-stranded RNA-activated (PRKR); Protein kinase RNA-activated (PKR)
Control of protein translation is a universal checkpoint that enables eukaryotic cells to respond to environmental challenge. Accordingly, it had been noted that virus infection halted host protein synthesis, and it was established that viral double-stranded (ds) RNA provoked this effect. A protein kinase, now designated PKR, was identified which phosphorylated the translation initiation factor 2α that accounted for this effect. It was subsequently demonstrated that this kinase was induced by interferon (IFN), establishing this enzyme as an effector molecule for the central antiviral response. It was subsequently shown...