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P2Y14 Receptor

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Encyclopedia of Signaling Molecules

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  • Abbracchio MP, Burnstock G, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, et al. International union of pharmacology LVIII. Update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev. 2006;58:281–341.

    PubMed  CAS  Google Scholar 

  • Arase T, Uchida H, Kajitani T, Ono M, Tamaki K, Oda H, et al. The UDPglucose receptor P2RY14 triggers innate mucosal immunity in the female reproductive tract by inducing IL-8. J Immunol. 2009;182:7074–84.

    PubMed  CAS  Google Scholar 

  • Bassil AK, Bourdu S, Townson KA, Wheeldon A, Jarvie EM, Zebda N, et al. UDP-glucose modulates gastric function through P2Y14 receptor-dependent and -independent mechanisms. Am J Physiol Gastrointest Liver Physiol. 2009;296:G923–30.

    PubMed  CAS  Google Scholar 

  • Brautigam VM, Dubyak GR, Crain JM, Watters JJ. The inflammatory effects of UDP-glucose in N9 microglia are not mediated by P2Y14 receptor activation. Purinergic Signal. 2008;4:73–8.

    PubMed  CAS  Google Scholar 

  • Carter RL, Fricks IP, Barrett MO, Burianek LE, Zhou Y, Ko H, et al. Quantification of Gi-mediated inhibition of adenylyl cyclase activity reveals that UDP is a potent agonist of the human P2Y14 receptor. Mol Pharmacol. 2009;76:1341–8.

    PubMed  CAS  Google Scholar 

  • Chambers JK, Macdonald LE, Sarau HM, Ames RS, Freeman K, Foley JJ, et al. A G protein-coupled receptor for UDP-glucose. J Biol Chem. 2000;275:10767–71. doi:10.1074/jbc.275.15.10767.

    PubMed  CAS  Google Scholar 

  • Communi D, Gonzalez NS, Detheux M, Brezillon S, Lannoy V, Parmentier M, Boeynaems JM. Identification of a novel human ADP receptor coupled to Gi. J Biol Chem. 2001;276:41479–85.

    PubMed  CAS  Google Scholar 

  • Das A, Zhou Y, Ivanov AA, Carter RL, Harden TK, Jacobson KA. Enhanced potency of nucleotide-dendrimer conjugates as agonists of the P2Y14 receptor: multivalent effect in G protein-coupled receptor recognition. Bioconjug Chem. 2009;20:1650–9.

    PubMed  CAS  Google Scholar 

  • Das A, Ko H, Burianek LE, Barrett MO, Harden TK, Jacobson KA. Human P2Y14 receptor agonists: Truncation of the hexose moiety of uridine-5′-diphosphoglucose and its replacement with alkyl and aryl groups. J Med Chem. 2010;53:471–80.

    PubMed  CAS  Google Scholar 

  • Deflorian F, Jacobson KA. Comparison of three GPCR structural templates for modeling of the P2Y12 nucleotide receptor. J Comput Aided Mol Des. 2011;25:329–38.

    PubMed  CAS  Google Scholar 

  • Fricks I, Maddiletti S, Carter R, Lazarowski ER, Nicholas RA, Jacobson KA, Harden TK. UDP is a competitive antagonist at the human P2Y14 receptor and a full agonist at the rat P2Y14 receptor. J Pharmacol Exp Therap. 2008;325:588–94.

    CAS  Google Scholar 

  • Gao ZG, Ding Y, Jacobson KA. UDP-glucose acting at P2Y14 receptors is a mediator of mast cell degranulation. Biochem Pharmacol. 2010;79:873–9.

    PubMed  CAS  Google Scholar 

  • Gauthier JY, Belley M, Deschênes D, Fournier JF, Gagné S, Gareau Y, et al. The identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y14. Bioorg Med Chem Lett. 2011;21:2836–9. doi:10.1016/j.bmcl.2011.03.081.

    PubMed  CAS  Google Scholar 

  • Guay D, Beaulieu C, Belley M, Crane SN, DeLuca J, Gareau Y, et al. Synthesis and SAR of pyrimidine-based, non-nucleotide P2Y14 receptor antagonists. Bioorg Med Chem Lett. 2011;21:2832–5. doi:10.1016/j.bmcl.2011.03.084.

    PubMed  CAS  Google Scholar 

  • Harden TK, Sesma JI, Fricks IP, Lazarowski ER. Signalling and pharmacological properties of the P2Y14 receptor. Acta Physiol. 2010;199:149–60. doi:10.1111/j.1748-1716.2010.02116.x.

    CAS  Google Scholar 

  • Kreda SM, Seminario-Vidal L, Heusden C, Lazarowski ER. Thrombin-promoted release of UDP-glucose from human astrocytoma cells. Br J Pharmacol. 2008;153:1528–37.

    PubMed  CAS  Google Scholar 

  • Lazarowski ER, Shea DA, Boucher RC, Harden TK. Release of cellular UDP-glucose as a potential extracellular signaling molecule. Mol Pharmacol. 2003;63:1190–7.

    PubMed  CAS  Google Scholar 

  • Muller T, Bayer H, Myrtek D, Ferrari D, Sorichter S, Ziegenhagen MW, et al. The P2Y14 receptor of airway epithelial cells: coupling to intracellular Ca2+ and IL-8 secretion. Am J Respir Cell Mol Biol. 2005;33:601–9.

    PubMed  Google Scholar 

  • Robichaud J, Fournier JF, Gagne S, Gauthier JY, Hamel M, Han Y, Henault M, Kargman S, Levesque JF, Yael Mamane Y, Mancini J, Morin N, Mulrooney E, Wu J, Black WC. Applying the pro-drug approach to afford highly bioavailable antagonists of P2Y14. Bioorg Med Chem Lett. 2011;21:4366–8.

    PubMed  CAS  Google Scholar 

  • Sesma JI, Esther CR, Kreda SM, Jones L, O’Neal W, Nishihara S, et al. Endoplasmic reticulum/golgi nucleotide sugar transporters contribute to the cellular release of UDP-sugar signaling molecules. J Biol Chem. 2009;284:12572–83.

    PubMed  CAS  Google Scholar 

  • Zippel N, Limbach CA, Ratajski N, Urban C, Pansky A, Luparello C, Kassack MU, Tobiasch E. Purinergic receptors influence the differentiation of human mesenchymal stem cells. Stem Cells Dev. 2011. doi:10.1089/scd.2010.0576.

    Google Scholar 

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Correspondence to Kenneth A. Jacobson .

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Jacobson, K.A., Jayasekara, M.P.S., Gao, ZG., Deflorian, F. (2012). P2Y14 Receptor. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0461-4_471

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