Reference work entry
p130Cas is a major substrate of the Src tyrosine kinase that functions in integrin signaling to promote cell motility, invasion, proliferation, and survival (reviewed by Defillipi et al. 2006; Tikhmyanova et al. 2010). p130Cas was first recognized in the late 1980s by immunoblot detection with an anti-phosphotyrosine antibody in cells transformed by retroviral oncogenes v- crk and v- src. The p130 designation indicates the apparent molecular mass of ∼130 kDa during SDS polyacrylamide gel electrophoresis (PAGE), and Cas is acronymic for “Crk-associated substrate.” Characterization of the direct interactions of p130Cas with the v-Crk and v-Src proteins was significant in the recognition of Src homology 2 (SH2) domains as phosphotyrosine-binding modules in signal transduction. p130Cas was independently identified as a...
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